Results 131 to 140 of about 506,706 (314)

Ubiquitination of secretory granules promotes their crinophagic degradation in Drosophila

FEBS Letters, EarlyView.
Ubiquitination of secretory granules in Drosophila larval salivary glands is a critical molecular trigger for crinophagy, the lysosomal degradation of unreleased, or low‐quality granules. The E3 ubiquitin ligase Cnot4 is recruited to the surface of secretory granules to induce crinophagy.
Tamás Csizmadia, Anna Dósa, Asha Kiran Maddali, András Jipa, Hajnalka Laczkó‐Dobos, Péter Lőw, Gábor Juhász   +6 more
wiley   +1 more source

Electron transfer between complexes III and IV in S. cerevisiae mitochondrial membranes

FEBS Letters, EarlyView.
Mitochondrial oxidative phosphorylation in S. cerevisiae mitoplasts is limited by complex IV catalytic capacity, rather than two‐dimensional cytochrome c diffusion. At physiological cytochrome c : supercomplex ratios at salinity equivalent to that of 20 mm monovalent salt, activity is maximized, indicating that this low ionic strength accurately mimics
Ana Paula Lobez, Mikael Oliveberg, Peter Brzezinski   +2 more
wiley   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Meaning in life and adolescent depression and anxiety in China: a large-scale study of dual pathways through life satisfaction and resilience

BMC Psychology
Background Adolescence is a formative yet vulnerable developmental period, marked by heightened emotional volatility and risk for depression and anxiety.
Lai Jiang, Xue Zeng, Hongbo He, Shi-Bin Wang   +3 more
doaj   +1 more source

The meaning of life and healing

, 2002
В. Д. Трошин
openalex   +1 more source

The Role of Psychiatric Symptoms, Social Support and Meaning in Life in Predicting Internet Addiction Among University Students: A Causal Model [PDF]

, 2018
Mohammad Ghaderi Rammazi, Ghasem Askarizadeh, Gholamreza Ahmadi, Kouros Divsalar   +3 more
openalex   +1 more source

Fortuin, Nienke P.M. (2020), The search for meaning in later life. An empirical exploration of religion and death, (Death Studies), Nijmegen Studies in Thanatology, Volume 6

, 2021
F. de Lange
openalex   +2 more sources

Modeling between primary maladaptive schemas and suicidal personality traits: mediation of the meaning of life in Gachsaran high school students [PDF]

, 2022
Zohreh Moradian, Armin Mahmoudi, Ali Taghvaeinia   +2 more
openalex   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Ethics, Religion, and the Problem of Life: Tolstoy’s Influence on Wittgenstein’s Thinking about the Meaning of Life

, 2023
Maksymilian Roszyk
openalex   +2 more sources