Results 161 to 170 of about 5,960,806 (253)

What are 'biohackers' hacking? Identifying motivations and meaning-making frameworks. [PDF]

Med Humanit
Lorrimar V.
europepmc   +1 more source

Flow Enabled Target Capture Halbach‐based magnetic enrichment increases circulating tumor cell capture from blood in metastatic cancer patients

Molecular Oncology, EarlyView.
Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens, Anouk Mentink, Tom Niessink, Frank Coumans, Leonie Mekenkamp, Ruchi Bansal, Jeroen Hiltermann   +6 more
wiley   +1 more source

Resilience as meaning-making: Adolescents' experiences of cyberbullying in post-conflict Ambon, Indonesia - a qualitative narrative study. [PDF]

Belitung Nurs J
Dewi NS, Lekatompessy R.
europepmc   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Negotiating uncertainty and responsibility after a vestibular schwannoma diagnosis: a qualitative study of meaning-making and surgical decision-making. [PDF]

BMC Psychol
Rutenkröger M, Nieke N, Brandes L, Scholl I.   +3 more
europepmc   +1 more source

Making meaning from trauma: An explorative phenomenological study into the experience of meaning-making

Meaning-making is commonly referred to as a phenomenon or process that supports healing and growth, including people’s recovery from life’s adverse and painful chapters. This study explored the complexities and nuances of the phenomenon of meaning-making,
Baker-Matamu, Merrion
core  

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

A Narrative Inquiry of Meaning Making and Leader Identity Development among College Students. [PDF]

New Dir Stud Leadersh
Sunderman HM, McCain KD, Orsini J, Pedersen T, Carlson E, Holst G.   +5 more
europepmc   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

End-of-Life Expectations and Meaning-Making Among First-Year Medical Residents: A Phenomenological Study in a Mexican General Hospital. [PDF]

Behav Sci (Basel)
Flores-Rosas JI, Jaramillo-Morales OA, Ruíz-Carlo JR, Vega-Cabrera NV, Torres-Martel JM, Recio-Chávez JD.   +5 more
europepmc   +1 more source