Results 121 to 130 of about 478,705 (259)

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Lifetime MDMA use and associations with meaning in life in the context of childhood trauma. [PDF]

Sci Rep
Olofsson M, Acar K, Simonsson O, Bragesjö M, White T, Almeida R, Petrovic P, Lebedev A.   +7 more
europepmc   +1 more source

The meaning of “human life” [PDF]

Nature, 1985
openaire   +2 more sources

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source

Meaning in Life Is Associated with Differing Motivations to Use Social Networking Sites. [PDF]

Behav Sci (Basel)
Rai R, Cheng MI, Farnell J.
europepmc   +1 more source

Methylation biomarkers can distinguish pleural mesothelioma from healthy pleura and other pleural pathologies

Molecular Oncology, EarlyView.
We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck, Nele De Meulenaere, Thomas Vanpoucke, Joe Ibrahim, Dieter Peeters, Suresh Krishan Yogeswaran, Wen Wen, Paul Van Schil, Jeroen M. H. Hendriks, Jo Raskin, Jan van Meerbeeck, Guy Van Camp, Ken Op de Beeck   +12 more
wiley   +1 more source

Well-being in the post-pandemic era: the role of meaning in life and resilience. [PDF]

Front Psychol
Baykal E, Contreras F, Abid G, Aldeanueva-Fernández I.   +3 more
europepmc   +1 more source

Detection of circulating tumor DNA in colorectal cancer patients using a methylation‐specific droplet digital PCR multiplex

Molecular Oncology, EarlyView.
We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto, Louise Raunkilde, Jan Lindebjerg, Mads Malik Aagaard, Christina Therkildsen, Jakob Kleif, Lars Henrik Jensen, Torben Frøstrup Hansen, Rikke Fredslund Andersen   +8 more
wiley   +1 more source

Impact of Moral Elevation on College Students’ Sense of Meaning of Life: The Mediating Roles of Gratitude and Perceived Social Support

Psychology Research and Behavior Management
Wen Sheng, Shuanghu Fang School of Educational Science, Anhui Normal University, Wuhu, People’s Republic of ChinaCorrespondence: Shuanghu Fang, Email fsh9075@163.comPurpose: The current study examined the association between moral elevation and college ...
Sheng W, Fang S
doaj  

The influence of social support and sentence length on meaning in life among incarcerated women in Ecuador. [PDF]

Front Psychol
Andrade LI, Viñán-Ludeña MS, Benitez J, Armijos G, Maldonado R.   +4 more
europepmc   +1 more source