Results 81 to 90 of about 7,923,904 (293)
FEBS Letters, EarlyView.Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi +5 more
wiley +1 more source
Organoids in pediatric cancer research
FEBS Letters, EarlyView.Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley +1 more source
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Oral History Interview: Elizabeth Means [PDF]
, 1989 These are a part of a series of interviews which Diana Parnicza conducted in the course of her project concerning Appalachian caregivers. Elizabeth Means (referred to in the interview as Caregiver #10) discusses: her family; a series of true/false ...
Means, Elizabeth
core
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
On a Conjecture on the Symmetric Means [PDF]
, 2006 In this paper, we study some inequalities involving the symmetric means. The main result is a proof of a conjecture of Alzer et al.
Gao, Peng
core +3 more sources
Swimming as important factor of development of physical abilities [PDF]
Pedagogìka, Psihologìâ ta Mediko-bìologìčnì Problemi Fìzičnogo Vihovannâ ì Sportu, 2012 The current state of health and physical fitness of young people, the complex of issues regarding the development of sports and mass swimming in Ukraine, in particular regarding training the ability to swim of the population and its conscripts have been ...
Popadin V.V. +2 more
doaj
Translation in the Teaching of a Foreign Language As a Means and As an End
TEFLIN Journal, 2002 In the history of foreign language teaching translation has alternately been praised and condemned. Unfortunately, the praise and condemnation were based on a rather simplistic, biased, and extreme view of the role of translation. In this view no clear,
Suparmin Suparmin
doaj +1 more source