Results 241 to 250 of about 6,711,621 (313)

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Correction: Marchetti et al. MicroRNA-24-3p Targets Notch and Other Vascular Morphogens to Regulate Post-ischemic Microvascular Responses in Limb Muscles. <i>Int. J. Mol. Sci</i>. 2020, <i>21</i>, 1733. [PDF]

Int J Mol Sci
Marchetti M, Meloni M, Anwar M, Al-Haj-Zen A, Sala-Newby G, Slater S, Ford K, Caporali A, Emanueli C.   +8 more
europepmc   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Segmenting Older Adults by Their Acceptance of Digital Health Care Devices: Cross-Sectional Study Using the Augmented Technology Acceptance Model and K-Means Clustering. [PDF]

JMIR Form Res
Koo T, Jo IH, Pyun DY, Yoo J.
europepmc   +1 more source

Nanobioconjugate Trispecific Antibody Augments Antitumor Immunity of Triple Negative Breast Cancer. [PDF]

Int J Nanomedicine
Chang Q, Liu L.
europepmc   +1 more source

Chromium propionate enhanced the production performance of yellow-feathered broilers under chronic heat stress exposure by improving intestinal health. [PDF]

Stress Biol
Chen J, Lei C, Guo X, Shao D, Guo C, Shi S.   +5 more
europepmc   +1 more source

Audiomotor prediction errors drive speech adaptation even in the absence of overt movement. [PDF]

PLoS Biol
Parrell B, Bae M, Naber C, Kim OA, Niziolek CA, McDougle SD.   +5 more
europepmc   +1 more source

Scaling <i>k</i>-Means for Multi-Million Frames: A Stratified NANI Approach for Large-Scale MD Simulations. [PDF]

J Chem Inf Model
Santos JBW, Chen L, Miranda-Quintana RA.
europepmc   +1 more source

Correction: When means and standard deviations are an incomplete summary of a continuous variable: problems, solutions, and utilising the reference ranges to check normality. [PDF]

BMJ Med
europepmc   +1 more source