Results 181 to 190 of about 4,197,310 (264)

Horsepower: equine-assisted interventions are associated with reduced PTSD symptoms, improved sleep quality, and quality of life in military veterans with treatment-resistant PTSD. [PDF]

Front Psychol
Kapteijn CM, Vermetten E, Rodenburg TB, Endenburg N.   +3 more
europepmc   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Dried Black Soldier Fly (<i>Hermetia illucens</i>) Larvae in a Sustainable Diet for Laying Hens: Effects on Welfare and Behavior. [PDF]

Animals (Basel)
Znazen Y, Gaddes M, Janssens GPJ, Ayed MH.   +3 more
europepmc   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Impact of personalized coaching on the use of digital health interventions for movement therapy in rheumatology: a randomized controlled trial. [PDF]

Sci Rep
Binder M, Temiz A, von Alten Blaskowitz PP, Coppers B, Ebner I, Petit P, Vuillerme N, Rudolf S, Schlaht V, Knitza J, Liphardt AM, Schett G, Morf H.   +12 more
europepmc   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Compensatory Fatty Acid Metabolism and Hepatic Gene Expression in African Catfish (<i>Clarias gariepinus</i>) Fed Marine-Ingredient-Free Circular Diets Low in EPA and DHA. [PDF]

Aquac Nutr
Shaw C, Knopf K, Wuertz S, Roy K, Gebauer R, Goldhammer T, Schöning V, Kleiner W, Sens M, Ulrichs C, Kloas W.   +10 more
europepmc   +1 more source

The therapeutic opportunities and pitfalls of using iron ion chelators to treat neurodegenerative diseases

FEBS Letters, EarlyView.
Although too much iron in the brain promotes neurodegeneration, iron ion chelators have had mixed effects in clinical trials. This review explains why; some chelators do not render the iron redox‐inactive (e.g., L1) whereas others do (e.g., desferrioxamine).
Barry Halliwell
wiley   +1 more source

Tomato drought-responsive transcription factor TINY1 suppresses embryonic growth. [PDF]

J Exp Bot
Azriel M, Shohat H, Blinderman D, Weiss D, Zait Y.   +4 more
europepmc   +1 more source