Results 201 to 210 of about 16,568,157 (301)

The case for mandatory reporting to enable targets for healthy and environmentally sustainable food: means, motive and opportunity. [PDF]

BMC Med
Pechey R, Bandy L, Jebb SA.
europepmc   +1 more source

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

Impact of polystyrene microplastic exposure at low doses on male fertility: an experimental study in rats. [PDF]

Sci Rep
Alsenousy AHA, Khalaf AHY, Ibrahim HZ, Kamel MA, Yousef MI.   +4 more
europepmc   +1 more source

RaMBat: Accurate identification of medulloblastoma subtypes from diverse data sources with severe batch effects

Molecular Oncology, EarlyView.
To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley   +1 more source

NLRP12 Deficiency Enhances Tofacitinib Efficacy in DSS Colitis Via STAT1-M1 Polarization. [PDF]

Inflammation
Yi Y, Wei Q, Chen S, Li L, Dekyi W, Jia H, Shu X, Zhao Q, Chang Y.   +8 more
europepmc   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Clustering-cum-regression based model and performance analysis for early prediction of heart disease. [PDF]

Sci Rep
Tolani M, AlZahrani Y, Suman G, Kumar P, Balodi A, Bajpai A.   +5 more
europepmc   +1 more source

Making Meaning [PDF]

Postgraduate Medical Journal, 2008
openaire   +1 more source