Results 211 to 220 of about 6,712,581 (313)

Antioxidant Capacity Alterations in Bangladeshi Underutilized Fruits: InsightsFrom In Vitro Gastrointestinal Digestion Studies. [PDF]

Int J Food Sci
Alam M, Mahmood S, Jahan N, Ove TA, Mozumder NHMR, Khatun H.   +5 more
europepmc   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Clustering Analysis of Ankle-Brachial Index Related Metabolic and Body Composition Profiles Using K-Means Approach. [PDF]

Vasc Health Risk Manag
Kristianto H, Irawan PLT, Susanto AH, Kusumaayu KA, Susita DA, Billah I, Aprillisna NZ, Ramadhani N.   +7 more
europepmc   +1 more source

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

Molecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi, Stavros Makrodimitris, Sandra van Wilpe, Iris te Paske, Vanja de Weerd, Corine M. Beaufort, Hans M. Westgeest, Jens Voortman, Maureen J. B. Aarts, Maud Rijnders, Astrid A. M. van der Veldt, Ronald de Wit, Niven Mehra, Saskia M. Wilting, Debbie G. J. Robbrecht   +14 more
wiley   +1 more source

The Meaning of Meaning

, 2014
  +5 more sources

Horsepower: equine-assisted interventions are associated with reduced PTSD symptoms, improved sleep quality, and quality of life in military veterans with treatment-resistant PTSD. [PDF]

Front Psychol
Kapteijn CM, Vermetten E, Rodenburg TB, Endenburg N.   +3 more
europepmc   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Impact of personalized coaching on the use of digital health interventions for movement therapy in rheumatology: a randomized controlled trial. [PDF]

Sci Rep
Binder M, Temiz A, von Alten Blaskowitz PP, Coppers B, Ebner I, Petit P, Vuillerme N, Rudolf S, Schlaht V, Knitza J, Liphardt AM, Schett G, Morf H.   +12 more
europepmc   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Dried Black Soldier Fly (<i>Hermetia illucens</i>) Larvae in a Sustainable Diet for Laying Hens: Effects on Welfare and Behavior. [PDF]

Animals (Basel)
Znazen Y, Gaddes M, Janssens GPJ, Ayed MH.   +3 more
europepmc   +1 more source