Results 51 to 60 of about 390,420 (292)

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

Preventive Detention on Remand in Pre-Trial Proceedings from the Point of View of Theory and Practice

Bratislava Law Review
In the article the authors pay attention to the detention on remand, which is the most serious procedural interference in the system of criminal law means to the personal liberty of an individual, accused of a crime.
Jozef Čentéš, Andrej Beleš
doaj   +1 more source

Changing Traditional Mechanisms of Russian Law: Protection of Means of Individualization on the Internet [PDF]

SSRN Electronic Journal, 2015
This article is motivated by the growing interest in the problem of Internet trademark usage and the comparatively low interest in the non-Internet equivalent. Despite the fact that differences in the regulation of on-line and off-line trademark utilization have been recognized over a long period of time, there is still no harmonization among the ...
openaire   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

ENSURING OF RADIATION PROTECTION DURING WORKS ON TRANSFORMATION OF THE OBJECT SHELTER INTO ECOLOGICALLY SAFE SYSTEM. BIOPHYSICAL MONITORING OF THE PERSONNEL INTERNAL EXPOSURE DOSES

Радиационная гигиена, 2017
Given paper, states the ensuring of the interpretation of the basic radiation protection principles, relative to the works at the Object Shelter (OS). Analysis of the factors of radiation situation at the OS is figured out.
S. Yu. Nechaev, I. A. Likhtarev, V. B. Berkovski, L. N. Kovgan, Yu. V. Bonchuk, G. G. Ratia, P. B. Aryasov   +6 more
doaj  

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

A differential privacy protecting K-means clustering algorithm based on contour coefficients. [PDF]

PLoS ONE, 2018
This paper, based on differential privacy protecting K-means clustering algorithm, realizes privacy protection by adding data-disturbing Laplace noise to cluster center point.
Yaling Zhang, Na Liu, Shangping Wang
doaj   +1 more source

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Criminal offenses against official duty with a focus on the object of the criminal offense

Pravo
The very title of the group of criminal offenses against official duty reveals their object of protection, which is the conscientious and responsible performance of official duties.
Mile Šikman, Velibor Bajičić
doaj   +1 more source