Results 51 to 60 of about 362,055 (276)

TOMM20 as a driver of cancer aggressiveness via oxidative phosphorylation, maintenance of a reduced state, and resistance to apoptosis

Molecular Oncology, EarlyView.
TOMM20 increases cancer aggressiveness by maintaining a reduced state with increased NADH and NADPH levels, oxidative phosphorylation (OXPHOS), and apoptosis resistance while reducing reactive oxygen species (ROS) levels. Conversely, CRISPR‐Cas9 knockdown of TOMM20 alters these cancer‐aggressive traits.
Ranakul Islam, Megan E. Roche, Zhao Lin, Diana Whitaker‐Menezes, Victor Diaz‐Barros, Eurico Serrano, Maria Paula Martinez Cantarin, Nancy J. Philp, Atrayee Basu Mallick, Ubaldo Martinez‐Outschoorn   +9 more
wiley   +1 more source

ENSURING OF RADIATION PROTECTION DURING WORKS ON TRANSFORMATION OF THE OBJECT SHELTER INTO ECOLOGICALLY SAFE SYSTEM. BIOPHYSICAL MONITORING OF THE PERSONNEL INTERNAL EXPOSURE DOSES

Радиационная гигиена, 2017
Given paper, states the ensuring of the interpretation of the basic radiation protection principles, relative to the works at the Object Shelter (OS). Analysis of the factors of radiation situation at the OS is figured out.
S. Yu. Nechaev, I. A. Likhtarev, V. B. Berkovski, L. N. Kovgan, Yu. V. Bonchuk, G. G. Ratia, P. B. Aryasov   +6 more
doaj  

Preventive Detention on Remand in Pre-Trial Proceedings from the Point of View of Theory and Practice

Bratislava Law Review
In the article the authors pay attention to the detention on remand, which is the most serious procedural interference in the system of criminal law means to the personal liberty of an individual, accused of a crime.
Jozef Čentéš, Andrej Beleš
doaj   +1 more source

A differential privacy protecting K-means clustering algorithm based on contour coefficients. [PDF]

PLoS ONE, 2018
This paper, based on differential privacy protecting K-means clustering algorithm, realizes privacy protection by adding data-disturbing Laplace noise to cluster center point.
Yaling Zhang, Na Liu, Shangping Wang
doaj   +1 more source

Transcriptome‐wide analysis of circRNA and RBP profiles and their molecular relevance for GBM

Molecular Oncology, EarlyView.
CircRNAs are differentially expressed in glioblastoma primary tumors and might serve as therapeutic targets and diagnostic markers. The investigation of circRNA and RNA‐binding proteins (RBPs) interactions shows that distinct RBPs play a role in circRNA biogenesis and function.
Julia Latowska‐Łysiak, Żaneta Zarębska, Marcin P. Sajek, Adriana Grabowska, Alessia Buratin, Paweł Głodowicz, Julia O. Misiorek, Konrad Kuczyński, Stefania Bortoluzzi, Marek Żywicki, Jan G. Kosiński, Agnieszka Rybak‐Wolf, Rafał Piestrzeniewicz, Anna M. Barciszewska, Katarzyna Rolle   +14 more
wiley   +1 more source

Preventing childhood malaria in Africa by protecting adults from mosquitoes with insecticide-treated nets. [PDF]

PLoS Medicine, 2007
Malaria prevention in Africa merits particular attention as the world strives toward a better life for the poorest. Insecticide-treated nets (ITNs) represent a practical means to prevent malaria in Africa, so scaling up coverage to at least 80% of young ...
Gerry F Killeen, Tom A Smith, Heather M Ferguson, Hassan Mshinda, Salim Abdulla, Christian Lengeler, Steven P Kachur   +6 more
doaj   +1 more source

PECULIARITIES OF EXTERNAL RESPIRATORY FUNCTIONS IN STUDENTS WHEN USING INDIVIDUAL PROTECTION MEANS [PDF]

, 2022
R.S. Alesich, I.S. Chub
openalex   +1 more source

Targeting the MDM2‐MDM4 interaction interface reveals an otherwise therapeutically active wild‐type p53 in colorectal cancer

Molecular Oncology, EarlyView.
This study investigates an alternative approach to reactivating the oncosuppressor p53 in cancer. A short peptide targeting the association of the two p53 inhibitors, MDM2 and MDM4, induces an otherwise therapeutically active p53 with unique features that promote cell death and potentially reduce toxicity towards proliferating nontumor cells.
Sonia Valentini, Giada Mele, Marika Attili, Maria Rita Assenza, Fulvio Saccoccia, Francesca Sardina, Cinzia Rinaldo, Roberto Massari, Nicola Tirelli, Alfredo Pontecorvi, Fabiola Moretti   +10 more
wiley   +1 more source

Issues faced by the determination of data ownership and solutions

大数据, 2021
As data becomes a key production factor, the determination of data ownership is becoming an important issue.Firstly, the problems that need to be solved urgently from perspectives of the government, enterprise, and individual brought by the unclear ...
Bo HE
doaj  

Inhibitor of DNA binding‐1 is a key regulator of cancer cell vasculogenic mimicry

Molecular Oncology, EarlyView.
Elevated expression of transcriptional regulator inhibitor of DNA binding 1 (ID1) promoted cancer cell‐mediated vasculogenic mimicry (VM) through regulation of pro‐angiogenic and pro‐cancerous genes (e.g. VE‐cadherin (CDH5), TIE2, MMP9, DKK1). Higher ID1 expression also increased metastases to the lung and the liver.
Emma J. Thompson, Emma L. Dorward, Kristyn Jurrius, Nathalie Nataren, Markus Tondl, Kay K. Myo Min, Michaelia P. Cockshell, Anahita Fouladzadeh, John Toubia, Mark DeNichilo, Delphine Merino, Claudine S. Bonder   +11 more
wiley   +1 more source