Results 61 to 70 of about 390,420 (292)

Issues faced by the determination of data ownership and solutions

大数据, 2021
As data becomes a key production factor, the determination of data ownership is becoming an important issue.Firstly, the problems that need to be solved urgently from perspectives of the government, enterprise, and individual brought by the unclear ...
Bo HE
doaj  

Soldier protection in the defence system against weapons of mass destruction [PDF]

Biuletyn Wojskowej Akademii Technicznej
This article addresses a very important and relevant issue of protecting the soldier on the modern battlefield. Military doctrinedocuments a lack information on individual soldier protection.
Władysław Harmata, Piotr Wachna
doaj   +1 more source

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source

Cell density–dependent nuclear‐cytoplasmic shuttling of SETDB1 integrates with Hippo signaling to regulate YAP1‐mediated transcription

FEBS Letters, EarlyView.
At low cell density, SETDB1 and YAP1 accumulate in the nucleus. As cell density increases, the Hippo pathway is gradually activated, and SETDB1 is associated with increased YAP1 phosphorylation. At high cell density, phosphorylated YAP1 is sequestered in the cytoplasm, while SETDB1 becomes polyubiquitinated and degraded by the ubiquitin–proteasome ...
Jaemin Eom, Jaewoong Jang, Jung Sun Park, Yong‐Kook Kang   +3 more
wiley   +1 more source

Measuring the Effectiveness of Control Mechanisms in Regional Human Rights Systems – from Conception to Execution

Przegląd Prawno-Ekonomiczny
The lowest level of protection is ensured under the domestic law of individual countries. The aim of the article is to develop a methodology for measuring the effectiveness of control mechanisms functioning within regional human rights protection ...
Jarosław Kowalski
doaj   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Readiness of senior higher school students for self-determination in ecology field as an ability to form subjective attitude

SHS Web of Conferences, 2016
The current state of environment demands from senior pupils to occupy a correct position in problem ecological situations. An effective means of forming senior pupils’ own position is activity in a field of ecology. Through a variety of activities in the
Titov Evgeny V., Cherkashin Evgeny I.
doaj   +1 more source

Effect of individual and community-level bed net usage on malaria prevalence among under-fives in the Democratic Republic of Congo

Malaria Journal, 2018
Background Understanding the contribution of community-level long-lasting, insecticidal net (LLIN) coverage to malaria control is critical to planning and assessing intervention campaigns.
Lauren Levitz, Mark Janko, Kashamuka Mwandagalirwa, Kyaw L. Thwai, Joris L. Likwela, Antoinette K. Tshefu, Michael Emch, Steven R. Meshnick   +7 more
doaj   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source