Results 71 to 80 of about 362,055 (276)
Revista da Sociedade Brasileira de Medicina Tropical, 2009 Relata-se novo surto de LTA em militares com 71 casos confirmados pelos critérios clínico, epidemiológico e laboratorial. Obteve-se o isolamento de sete amostras, identificadas como Leishmania (Viannia) braziliensis.
Maria Sandra Andrade +5 more
doaj +1 more source
Molecular Oncology, EarlyView.The pan‐HDAC inhibitor belinostat increases the expression of the pro‐apoptotic proteins Bim, Puma, and Noxa and induces apoptosis in ovarian cancer cell lines and patient‐derived tumor organoids when used at high concentrations. Moreover, inhibiting the anti‐apoptotic proteins Bcl‐xL or Mcl‐1 sensitizes these preclinical models to the cytotoxic effect
Cécilia Thomine +10 more
wiley +1 more source
Systematic profiling of cancer‐fibroblast interactions reveals drug combinations in ovarian cancer
Molecular Oncology, EarlyView.Fibroblasts, cells in the tumor environment, support ovarian cancer cell growth and alter morphology and drug response. We used fibroblast and cancer cell co‐culture models to test 528 drugs and discovered new drugs for combination treatment. We showed that adding Vorinostat or Birinapant to standard chemotherapy may improve drug response, suggesting ...
Greta Gudoityte +10 more
wiley +1 more source
La formulation contractuelle de l’intérêt général entre droits et intérêts particuliers
Astérion, 2017 By making the individual rights the anthropological premise of society, modernity subverted the essence of the common good which is now defined with regard to individual aspirations. The general interest can no longer be regarded as an end.
Florence Perrin
doaj +1 more source
MODELING OF ELEMENTS OF THE "SMALL ARMS – BARREL – BULLET" SYSTEM USING THE FINITE ELEMENT METHOD
Надежность и качество сложных систем, 2023 Background. Small arms are an integral part of modern combat. In connection with the development of armor protection means, it is required to increase the effectiveness of individual small arms. Materials and methods.
A.A. Gromov +3 more
doaj +1 more source
Molecular Oncology, EarlyView.Trastuzumab‐deruxtecan, a HER2‐targeting antibody‐drug conjugate, shows promising antitumor activity in head and neck squamous cell carcinoma with low HER2 expression. In vitro and in vivo studies demonstrated dose‐dependent cell death and tumor growth reduction in low HER2‐expressing cell lines, which correlated with drug accumulation measured using a
Abdullah Bin Naveed +8 more
wiley +1 more source
The Politics, Practice and Paradox of ‘Ethnic Security’ in Bosnia-Herzegovina
Stability : International Journal of Security and Development, 2015 The international intervention in Bosnia-Herzegovina was intended to support conflict resolution by introducing territorial self-government and power sharing as the foundation for a governance framework that would provide for collective and individual ...
Vesna Bojicic-Dzelilovic
doaj +1 more source
Molecular Oncology, EarlyView.Loss of primary cilia in endothelial cells promotes EndMT and vascular abnormalities in the ovarian tumor microenvironment through EphA2 activation. Using human samples, in vitro models, and endothelial‐specific Kif3a‐knockout mice, we show that primary cilia loss drives the acquisition of cancer‐associated fibroblast‐like phenotypes, thereby ...
Jin Gu Cho +11 more
wiley +1 more source
Cogent Social SciencesThe contentious nature of certain forms of climate activism has led to a proliferation of hate comments targeting activists in online news forums.
Andreas Schulz-Tomančok +1 more
doaj +1 more source
Genomics‐led approach to drug testing in models of undifferentiated pleomorphic sarcoma
Molecular Oncology, EarlyView.GA text Genomic data from undifferentiated pleomorphic sarcoma patients and preclinical models were used to inform a targeted drug screen. Selected compounds were tested in 2D and 3D cultures of UPS cell lines. A combination of trametinib and infigratinib was synergistic in the majority of UPS cell lines tested, which was further confirmed in an ex ...
Piotr J. Manasterski +19 more
wiley +1 more source