Results 81 to 90 of about 362,055 (276)
Availability Analysis of Different PON Models
Journal of Telecommunications and Information Technology, 2017 Due to the increasing demands of individual users, Passive Optical Networks (PON) are a promising technology for future broadband access networks. Reliable access to network services is a very important feature, so the availability of the connection is ...
Katarina Radosˇ, Ivan Rados
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‘Means for the protection of rights vs. legal certainty’ as a dilemma of the domestic official constitutional doctrine in the context of functioning of the institute of individual constitutional complaint [PDF]
, 2020 Yurii Barabash
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A nucleotide‐independent, pan‐RAS‐targeted DARPin elicits anti‐tumor activity in a multimodal manner
Molecular Oncology, EarlyView.We report a Designed Ankyrin Repeat Protein that binds and inhibits RAS proteins, which serve as central cell signaling hubs and are essential for the progression of many cancers. Its unique feature is that it does not discriminate between different RAS isoforms or mutations and is capable of binding to RAS in both its active (GTP‐bound) and inactive ...
Jonas N. Kapp +13 more
wiley +1 more source
Molecular Oncology, EarlyView.Overexpression of CHRDL2 in colon cancer cells makes them more stem‐like and resistant to chemo‐ and radiotherapy. CHRDL2‐high cells have upregulation of the WNT pathway, genes involved in the DNA damage response (DDR) pathway and epithelial‐to‐mesenchymal transition (EMT). This leads to quicker repair of damaged DNA and more cell migration.
Eloise Clarkson, Annabelle Lewis
wiley +1 more source
Molecular Oncology, EarlyView.TRIM24 and TRIM28 are androgen receptor (AR) coregulators which exhibit increased expression with cancer progression. Both TRIM24 and TRIM28 combine to influence the response of castrate‐resistant prostate cancer (CRPC) cells to AR inhibitors by mediating AR signalling, regulation of MYC and upregulating VEGF to promote angiogenesis. Castrate‐resistant
Damien A. Leach +8 more
wiley +1 more source
Attacks against Cultural Property in Armed Conflict – How to Reduce the Risk of Impunity?
Santander Art & Culture Law ReviewPeople see cultural property as their heritage, which identifies them and made them who they are today.
Nout van Woudenberg
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Chimeric diphtheria toxin–CCL8 cytotoxic peptide for breast cancer management
Molecular Oncology, EarlyView.DTCCL8 is a recombinant fusion toxin that targets cancer cells expressing chemokine receptors. By combining diphtheria toxin with CCL8, DTCCL8 binds to multiple receptors on tumor cells and induces selective cytotoxicity. This strategy enables receptor‐mediated targeting of cancer and may support the development of chemokine‐guided therapeutics ...
Bernardo Chavez +5 more
wiley +1 more source
Molecular Oncology, EarlyView.In prostate carcinoma, lactic acid, secreted by highly glycolytic cancer‐associated fibroblasts, is imported into tumor cells through the MCT1 transporter and prevents RSL3 and erastin‐induced ferroptosis (A). Targeting of carbonic anhydrase IX/XII, the main extracellular pH regulators, in tumor and stromal cells reduces microenvironmental acidosis and
Elisa Pardella +18 more
wiley +1 more source
Microssystem of environmental law: formation and operability
Scientia Iuris, 2018 Our modern legal system was built from large and traditional codifications of private law, with the objective of safeguarding individual liberties and rights.
Jussara Suzi Assis Borges Nasser Ferreira +1 more
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