Results 41 to 50 of about 236,843 (271)

Endogenous Engineering Reprograms Extracellular Vesicles for Enhanced Therapeutic Function

Advanced Science, EarlyView.
This review explains how Extracellular vesicles‐producing cells can be endogenously engineered to load therapeutic proteins and nucleic acids. We summarize physiological and genetic strategies that harness native sorting pathways for selective cargo loading.
Jinghui Wang, Wenxuan Zhao, Xiaoming Hu, Yishu Wang, Peidong Yang, Diwei Zheng, Yugang Wang, Guanghui Ma, Min Shi, Wei Wei, Shuang Wang   +10 more
wiley   +1 more source

Genetic characterization of measles virus circulating in Iran, 2021–2023

BMC Infectious Diseases
Background Measles, an ongoing public health concern, demands continuous molecular surveillance and virus characterization for elimination. Despite Iran achieving measles elimination status in 2019 through robust molecular testing and vaccination, the ...
Alireza Esmaeiloghli Amiryli, Simin Abbasi, Faezeh Tarpoor, Azadeh Shadab, Azam Saboori, Nazanin-Zahra Shafiei Jandaghi, Vahid Salimi, Talat Mokhtari-Azad   +7 more
doaj   +1 more source

Development and evaluation of a next-generation sequencing methodology for measles virus using Oxford Nanopore Technology

Journal of Clinical Microbiology
We report the development of a bench protocol and evaluation of bioinformatics pipelines for the whole genome sequence (WGS) of measles virus (MeV) genotype D8. We established a bench protocol using 1 kb amplicons tiling the MeV WGS.
Vanessa Zubach, Gurasis Osahan, Kurt Kolsun, Claudia Pfeifer, Alberto Severini, Joanne Hiebert   +5 more
doaj   +1 more source

Measles in a measles-eliminated country: A case report of a measles-infected postpartum mother and infant in Japan

IDCases, 2021
Japan has maintained measles elimination status since 2015. However, sporadic outbreaks of measles have been continuously reported. Here, we report a case of a measles-infected postpartum mother and infant in Japan.
Haruki Mito, Ryota Hase, Nozomu Oshima, Hiroyuki Ikeda   +3 more
doaj   +1 more source

Canine distemper virus neutralization activity is low in human serum and it is sensitive to an amino acid substitution in the hemagglutinin protein [PDF]

, 2015
© 2015 Elsevier Inc.Serum was analyzed from 146 healthy adult volunteers in eastern Africa to evaluate measles virus (MV) and canine distemper virus (CDV) neutralizing antibody (nAb) prevalence and potency.
Allen, S, Anzala, O, Domi, A, Driscoll, J, Fast, P, Gilmour, J, Kamali, A, Karita, E, Parks, CL, Price, MA, Sanders, EJ, Wallace, OL, Wright, KJ, Zhang, X   +13 more
core   +1 more source

Atypical Clinical Course of Griscelli Syndrome Type 2 With Primarily Neurologic Presentation and Adult‐Onset in a 46‐Year‐Old Male

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Griscelli Syndrome Type 2 (GS2) is a rare autosomal recessive disorder caused by pathogenic mutations in the RAB27A gene. Typically, it is characterized by cutaneous hypopigmentation, immunodeficiency, with or without neurological abnormalities secondary to hemophagocytic lymphohistiocytosis (HLH). Without treatment, GS2 often results in fatal
Dzhoy Papingi, Michael Kutsche, Helena Lichtenfeld, Fanny Kortüm, Angela Abicht, Laura Herrmann, Theresia Herget   +6 more
wiley   +1 more source

Evaluating the (comparative) safety profile of the novel oral polio vaccine type 2 using individual case safety reports in VigiBase

British Journal of Clinical Pharmacology, EarlyView.
Aim Novel oral polio vaccine type 2 (nOPV2) was used under the WHO emergency use listing for circulating vaccine‐derived polio virus (cVDPV) outbreaks from 2021 to 2023. We assessed nOPV2 adverse events following immunization (AEFIs) and compared its safety profile to other vaccines using VigiBase.
Comfort Kunak Ogar, Malede Mequanent Sisay, Leonardo Roque‐Pereira, Christine Leopold, Patrick C. Souverein, Aukje K. Mantel‐Teeuwisse, Marie L. De Bruin   +6 more
wiley   +1 more source

Novel Polyomaviruses in Mammals from Multiple Orders and Reassessment of Polyomavirus Evolution and Taxonomy

Viruses, 2019
As the phylogenetic organization of mammalian polyomaviruses is complex and currently incompletely resolved, we aimed at a deeper insight into their evolution by identifying polyomaviruses in host orders and families that have either rarely or not been ...
Bernhard Ehlers, Augustin E. Anoh, Nicole Ben Salem, Sebastian Broll, Emmanuel Couacy-Hymann, Daniela Fischer, Alma Gedvilaite, Nanina Ingenhütt, Sonja Liebmann, Maite Martin, Arsene Mossoun, Lawrence Mugisha, Jean-Jacques Muyembe-Tamfum, Maude Pauly, Bernat Pérez de Val, Hannah Preugschas, Dania Richter, Grit Schubert, Claudia A. Szentiks, Tamara Teichmann, Cornelia Walter, Rainer G. Ulrich, Lidewij Wiersma, Fabian H. Leendertz, Sébastien Calvignac-Spencer   +24 more
doaj   +1 more source

The role of research in viral disease eradication and elimination programs: Lessons for malaria eradication [PDF]

, 2011
By examining the role research has played in eradication or regional elimination initiatives for three viral diseases-smallpox, poliomyelitis, and measles-we derive nine cross-cutting lessons applicable to malaria eradication.
Breman, JG, de Quadros, CA, Dowdle, WR, Foege, WH, Henderson, DA, John, TJ, Levine, MM   +6 more
core   +1 more source

Viruses disrupt functions of human lymphocytes. Effects of measles virus and influenza virus on lymphocyte-mediated killing and antibody production. [PDF]

, 1984
We present experimental data that offer, in part, a better understanding of the immunosuppression that accompanies measles virus infection. We note that measles virus "silently" infects human lymphocytes and that the infection does not alter lymphocyte ...
Casali, P, Oldstone, MB, Rice, GP
core