Results 11 to 20 of about 1,829,163 (317)
Measles Virus as an Oncolytic Immunotherapy [PDF]
Cancers, 2021 Measles virus (MeV) preferentially replicates in malignant cells, leading to tumor lysis and priming of antitumor immunity. Live attenuated MeV vaccine strains are therefore under investigation as cancer therapeutics. The versatile MeV reverse genetics systems allows for engineering of advanced targeted, armed, and shielded oncolytic viral vectors ...
Christine E. Engeland, Guy Ungerechts
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Measles to the Rescue: A Review of Oncolytic Measles Virus [PDF]
Viruses, 2016 Oncolytic virotherapeutic agents are likely to become serious contenders in cancer treatment. The vaccine strain of measles virus is an agent with an impressive range of oncolytic activity in pre-clinical trials with increasing evidence of safety and efficacy in early clinical trials.
Aref, S, Bailey, K, Fielding, A
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Uirusu, 2017 Measles virus (MeV) is exceptionally contagious and still a major cause of death in child.However, recently significant progress towards the elimination of measles has been made through increased vaccination coverage of measles-containing vaccines. The hemagglutinin (H) protein of MeV interacts with a cellular receptor, and this interaction is the ...
Maino, Tahara, Makoto, Takeda
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Human Vaccines & Immunotherapeutics, 2014 Measles was an inevitable infection during the human development with substantial degree of morbidity and mortality. The severity of measles virus (MV) infection was largely contained by the development of a live attenuated vaccine that was introduced into the vaccination programs.
H. Naim
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Autophagy in Measles Virus Infection [PDF]
Viruses, 2017 Autophagy is a biological process that helps cells to recycle obsolete cellular components and which greatly contributes to maintaining cellular integrity in response to environmental stress factors. Autophagy is also among the first lines of cellular defense against invading microorganisms, including viruses.
Rozières, Aurore +2 more
openaire +6 more sources
Science Advances, 2020 Measles virus proteins form liquid droplets where they can encapsidate their genomic material. Many viruses are known to form cellular compartments, also called viral factories.
Serafima Guseva +7 more
semanticscholar +1 more source
Measles virus and rinderpest virus divergence dated to the sixth century BCE
Science, 2020 Older origins of measles virus Animal domestication by humans is thought to have given many pathogens an opportunity to invade a new host, and measles is one example of this. However, there is controversy about when measles emerged in humans, because the
A. Düx +20 more
semanticscholar +1 more source
Leukemia, 2020 Oncolytic virus therapy leads to immunogenic death of virus-infected tumor cells and this has been shown in preclinical models to enhance the cytotoxic T-lymphocyte response against tumor-associated antigens (TAAs), leading to killing of uninfected tumor
N. Packiriswamy +9 more
semanticscholar +1 more source
Journal of dentistry research, 2020 Dental health care workers are in close contact to their patients and are therefore at higher risk for contracting airborne infectious diseases. The transmission rates of airborne pathogens from patient to dental health care workers are unknown. With the
C. Zemouri +5 more
semanticscholar +1 more source
A highly immunogenic and effective measles virus-based Th1-biased COVID-19 vaccine
Proceedings of the National Academy of Sciences of the United States of America, 2020 Significance The COVID-19 pandemic has already caused over 1 million deaths. Therefore, effective vaccine concepts are urgently needed. In search of such a concept, we have analyzed a measles virus-based vaccine candidate targeting SARS-CoV-2. Using this
Cindy Hörner +10 more
semanticscholar +1 more source