Results 91 to 100 of about 4,370,635 (298)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

From a packing problem to quantitative recurrence in [0,1] and the Lagrange spectrum of interval exchanges

Discrete Analysis, 2017
From a packing problem to quantitative recurrence in [0,1] and the Lagrange spectrum of interval exchanges, Discrete Analysis 2017:10, 25 pp. A basic fact in the theory of Diophantine approximation is Dirichlet's theorem that for every real number ...
Michael Boshernitzan, Vincent Delecroix
doaj   +1 more source

تحليل سوسيولوجية التاريخ الشيعي المبكر باستخدام أدوات الذكاء الاصطناعي (الكيسانية بوصفها نموذجًا لتحول الحركة السياسية إلى عقيدة انتظار) [PDF]

Maǧallaẗ Kulliyyaẗ Al-ādāb Ǧāmiʿaẗ Būrsaʿīd
يسعى هذا البحث إلى تقديم قراءة سوسيولوجية جديدة للتاريخ الشيعي المبكر من خلال توظيف أدوات الذكاء الاصطناعي وتحليل النصوص الرقمية، متخذًا من الكِيسَانِيَّة نموذجًا لتحول الحركة السياسية الاحتجاجية إلى عقيدة انتظار ذات بعد مهدوي.
محمد أحمد طاهر عبدالرحمن النقيب
doaj   +1 more source

Generic behaviour of a measure preserving transformation

, 2017
We study two different problems: generic behavior of a measure preserving transformation and extending partial isometries of a compact metric space. In Chapter $1$, we consider a result of Del Junco--Lema\'nczyk [\ref{DL_B}] which states that a generic ...
Etedadialiabadi, Mahmood
core  

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

A Knowledge and Evaluation Model to Support the Conservation of Abandoned Historical Centres in Inner Areas

Heritage
The planning of interventions aimed at preserving the built heritage of inner areas is a complex process due to the fragility of these contexts. It should stem from adequate knowledge to support the recognition of qualities, resources, and potentials ...
Maria Rosa Trovato, Deborah Sanzaro
doaj   +1 more source

Post-Release Electronic Monitoring of Repeat Theft Offenders as a Security Measure [PDF]

Faṣlnāmah-i Pizhūhish-i Huqūq-i Kiyfarī
Research ProblemContemporary criminal law has gradually shifted from a reactive model centered on completed offences towards preventive strategies designed to manage future risks.
Shahram Ebrahimi, Hossein Soltanifar
doaj   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Ergodicity and entropy in sequence spaces [PDF]

, 2013
The infinite permutations of possible moves in a game, or positions on a game board, form a one-sided sequence space. We are working with a probability measure on the space of measurable subsets of the sequence space.
NC DOCKS at Western Carolina University, Miglino, Christopher   +1 more
core  

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source