Results 61 to 70 of about 4,370,635 (298)
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
LandRural areas are undergoing a transformation, shifting from traditional agriculture to green and leisure industries, driven by urban–rural imbalances and environmental challenges. This transition, however, presents the growing conflicts between preserving
Wenzhu Zhou +3 more
doaj +1 more source
The Evaluation of Secondary Schools in Jamaica A Value-Added Approach [PDF]
, 2021 This policy brief summarizes the new value-added method for evaluating Jamaica’s schools, explains the composite value-added measure derived from it, and presents the findings of the first complete application of the method to the evaluation of the ...
Jamaica Education Transformation Commission
core
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Terapi Bekam Thibb al-Nabawi pada Era Modern: Kajian Living Hadis
Islamic ReviewThis study examines the application of cupping therapy in the context of Thibb al-Nabawi, or the medicine of Prophet Muhammad saw. The author uses qualitative methods and field research to analyze the benefits of cupping therapy and its relevance in the ...
Muhammad Zainnurrofiq +3 more
doaj +1 more source
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
BuildingsWith the development of China’s social economy and urbanization, there is a significant stock of urban industrial architectural heritage. Considering the increasing demand for urban land and the renewal of idle sites, the reuse of industrial ...
Qiguo Li, Yao Zhang, Chao Wen
doaj +1 more source
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
ITEGAM-JETIASoftware defect prediction plays a crucial role in improving software reliability, reducing maintenance costs, and enhancing software quality.
Ruckmani V. S +3 more
doaj +1 more source