Results 31 to 40 of about 11,759 (233)

War as Peace Enforcement. On the Issue of the Dialectics of War and Peace in Modern International Relations

open access: yesУправленческое консультирование
The problems of war and peace throughout the history of mankind remain the most discussed issues. Their solution is not only of purely theoretical interest, but also has an impact on the development of international law and relations between states ...
N. I. Bezlepkin, V. I. Bashukov
doaj   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

On invariants for measure preserving transformations [PDF]

open access: yesFundamenta Mathematicae, 2001
This paper applies the theory of definable equivalence relations developed in descriptive set theory to the study of the isomorphism relation among measure preserving transformations. Two invertible measure preserving transformations on the unit interval \(\sigma_1\) and \(\sigma_2\) are isomorphic if there exists another such transformation \(\pi ...
openaire   +2 more sources

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

CORPOREALITY IN THE AGE OF POSTHUMANISM: ANTAEISM AS A HUMAN PRACTICE OF ROOTEDNESS

open access: yesОсвітній дискурс
Relevance of the research. The beginning of the twenty-first century has been marked by radical transformations in the modes of human existence driven by the accelerated development of technologies, including bioengineering and genetic engineering. These
Denys Fen
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

open access: yesFEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa   +5 more
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

open access: yesFEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

open access: yesFEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura   +2 more
wiley   +1 more source

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

open access: yesFEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil   +4 more
wiley   +1 more source

Spectral multiplicities of infinite measure preserving transformations [PDF]

open access: yesFunctional Analysis and Its Applications, 2010
Each subset $E\subset\Bbb N$ is realized as the set of essential values of the multiplicity function for the Koopman operator of an ergodic conservative infinite measure preserving transformation.
Danilenko, A. I., Ryzhikov, V. V.
openaire   +2 more sources

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