Results 81 to 90 of about 3,368,782 (269)
Molecular Oncology, EarlyView.Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley +1 more source
LOT: Logic Optimization with Testability - new transformations for logic synthesis [PDF]
, 1998 A new approach to optimize multilevel logic circuits is introduced. Given a multilevel circuit, the synthesis method optimizes its area while simultaneously enhancing its random pattern testability.
Kunz, Wolfgang +5 more
core
PANoptosis in the pathogenesis of myelodysplastic syndromes
Molecular Oncology, EarlyView.PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla +4 more
wiley +1 more source
Ergodic Measure Preserving Transformations of Finite Type
Tokyo Journal of Mathematics, 1988 Let T be an invertible ergodic measure preserving (e.m.p.) transformation of an infinite \(\sigma\)-finite Lebesgue measure space (X,\({\mathcal B},m)\). A set W is called weakly wandering (w.w.) if there exists a strictly increasing sequence \((n_ i)\) of integers such that \(T^{n_ i}W\cap T^{n_ j}W=\emptyset\) for \(i\neq j\); and \((n_ i)\) is ...
EIGEN, Stanley +2 more
openaire +3 more sources
Spatial biology in cancer epigenetics
Molecular Oncology, EarlyView.Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley +1 more source
Groups of measure preserving transformations
Mathematische Annalen, 1988 Let G be a group of measure-preserving transformations on a non-atomic probability measure space \((X,{\mathcal B},\mu)\) (if we are interested in the according topological versions we assume that G is locally compact and the action on the sets \(A\in {\mathcal B}\) is continuous with respect to the metric \(\rho (A,B)=\mu (A\Delta B)).\) The main ...
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ADP‐ribosylation: An emerging regulator of the epigenome
Molecular Oncology, EarlyView.ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho +2 more
wiley +1 more source
Algebraic Models for Measure Preserving Transformations [PDF]
Transactions of the American Mathematical Society, 1968 Dinculeanu, Nicolae, Foiaș, Ciprian
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Molecular Oncology, EarlyView.Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou +4 more
wiley +1 more source
Molecular Oncology, EarlyView.Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley +1 more source