Results 51 to 60 of about 121,440 (234)

Claudin‐6 Protein Expression in Atypical Teratoid/Rhabdoid Tumors Is Strongly Enriched in the Molecular Subgroup AT/RT‐TYR

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Claudin‐6 has emerged as a promising immunotherapeutic target, yet protein‐level data in atypical teratoid/rhabdoid tumors (AT/RTs) have been inconsistent. We analyzed 36 well‐characterized AT/RT samples and found membranous claudin‐6 protein expression in 58% of cases, with striking enrichment in the molecular subgroup AT/RT‐TYR (100%) and ...
Victoria E. Fincke, Christian Thomas, Michael C. Frühwald, Pascal D. Johann, Martin Hasselblatt   +4 more
wiley   +1 more source

Genetic association mapping via evolution-based clustering of haplotypes. [PDF]

, 2007
Multilocus analysis of single nucleotide polymorphism haplotypes is a promising approach to dissecting the genetic basis of complex diseases. We propose a coalescent-based model for association mapping that potentially increases the power to detect ...
Ioanna Tachmazidou, Maria De Iorio, Claudio J. Verzilli, De Iorio, Maria, De Iorio, M, Claudio J Verzilli, Verzilli, Claudio J, Tachmazidou, I, Tachmazidou, Ioanna, Verzilli, CJ   +9 more
core   +1 more source

Time Toxicity in Wilms Tumor: Quantifying the Burden of Healthcare Interaction in the First Year After Diagnosis

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Wilms tumor (WT) treatment imposes a significant time burden on patients and their families. Time toxicity is a patient‐centered metric that quantifies the burden of healthcare interaction. We sought to define time toxicity in the first year after diagnosis of WT and hypothesized that it would increase as tumor stage and treatment ...
Caleb Q. Ashbrook, Veerain Gupta, Nicholas J. Clark, Vijay Rings, Lauren E. Corona, Douglass B. Clayton, Daniel J. Benedetti   +6 more
wiley   +1 more source

Modelado de parejas aleatorias usando cópulas

Revista Colombiana de Estadística, 2009
Las cópulas se han convertido en una herramienta útil para el modelado multivariado tanto estocástico como estadístico. En este artículo se revisan propiedades fundamentales de las cópulas que permitan caracterizar la estructura de dependencia de ...
GABRIEL ESCARELA, ANGÉLICA HERNÁNDEZ
doaj  

Measures of association for identifying microRNA-mRNA pairs of biological interest.

PLoS ONE, 2012
MicroRNAs are a class of small non-protein coding RNAs that play an important role in the regulation of gene expression. Most studies on the identification of microRNA-mRNA pairs utilize the correlation coefficient as a measure of association. The use of
Vivek Jayaswal, Mark Lutherborrow, Yee Hwa Yang   +2 more
doaj   +1 more source

Measurement-To-Track Association For Nontraditional Measurements

, 2011
Data fusion algorithms must typically address not only kinematic issues—that is, target tracking—but also nonkinematics—for example, target identification, threat estimation, intent assessment, etc. Whereas kinematics involves traditional measurements such as radar detections, nonkinematics typically involves nontraditional measurements such as ...
openaire   +3 more sources

A validation of a new measure of activity in psychosis

, 2006
Despite demonstrated relationships between activity and clinical change, we lack effective measures of time use in psychosis. Existing time budget measures of activity are demanding to complete, and thus unsuited to routine clinical use as measures of ...
Garety, PA, Dunn, Graham, Bebbington, P E, Freeman, D, Dunn, G., Dunn, G, Bebbington, PE, Jolley, S., Bebbington, P.E., Garety, P A; id_orcid, Ellett, L, Kuipers, E; id_orcid, Kuipers, Elizabeth, Fowler, DG, Garety, Philippa A., Fowler, G., Fowler, D G, Kuipers, E, Garety, P.A., Fowler, David G., Bebbington, Paul E., Freeman, D., Freeman, Daniel, Jolley, Suzanne, Jolley, S, Ellett, Lyn, Kuipers, E.   +26 more
core   +1 more source

Heterogeneity in the Global Practice of Central Nervous System Staging in Pediatric Acute Lymphoblastic Leukemia

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Central nervous system (CNS) involvement in childhood acute lymphoblastic leukemia (ALL) is assessed by cell counting and cytomorphology from cerebrospinal fluid (CSF) and is used for treatment stratification worldwide. The ratio of “CNS2” patients in clinical trials ranges from 3% to 40%, with unclear prognostic significance ...
Laura Almási, Bernadett Borbála Huszti, Gábor Barna, Marko Kavcic, Janez Jazbec, Lennart Lenk, Vera Münch, Sophia Polychronopoulou, Ágnes Márk, Maria Thastrup, Lüder H. Meyer, Kjeld Schmiegelow, Cornelia Eckert, Christina Halsey, Dániel J. Erdélyi   +14 more
wiley   +1 more source

The Individual Deprivation Measure::A Gender-Sensitive Approach to Poverty Measurement [PDF]

, 2016
Ground-breaking participatory research, feminist analysis and rights-based conceptual work underpin the Individual Deprivation Measure. The research was undertaken through a four-year, international, interdisciplinary research collaboration, led by the ...
Castillo, Fatima, Jaggar, Alison, Pogge, Thomas, Liu, Amy, Wisor, Scott, Crawford, Joanne, Bessell, Sharon, Donaghue, Kieran, Hunt, Janet   +8 more
core   +2 more sources

Emapalumab for Immune Effector Cell‐Associated Hemophagocytic Lymphohistiocytosis‐Like Syndrome Following CD19‐Directed CAR‐T in Two Patients With B‐ALL: Clinical and Biomarker Correlates

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Immune effector cell‐associated hemophagocytic lymphohistiocytosis‐like syndrome (IEC‐HS) is a life‐threatening hyperinflammatory toxicity distinct from cytokine release syndrome (CRS) and neurotoxicity following chimeric antigen receptor T‐cell (CAR‐T) therapy. In a single‐institution retrospective cohort of pediatric and young adult patients
Thomas J. Galletta, Jeremy D. Rubinstein, Christopher E. Dandoy, Ruby Khoury, Angela Faulhaber, Christine L. Phillips, Christa Krupski   +6 more
wiley   +1 more source