Results 111 to 120 of about 123,114 (281)

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Solvability of m-product mixed non-linear functional integral equations

Beni-Suef University Journal of Basic and Applied Sciences
The purpose of this paper is devoted to establishing the existence of solutions for m-product non-linear functional integral equations with weakly singular and Riemann–Liouville integral terms.
Amar Deep, Manochehr Kazemi, Mohammad Ali Fariborzi Araghi, Mohammad Esmael Samei   +3 more
doaj   +1 more source

Applications of one inequality to measures of non-compactness and narrow operators [PDF]

Mathematical Inequalities & Applications, 2019
A version of the Dubinskii-Lions-Magenes inequality [\textit{Yu. A. Dubinskij}, Mat. Sb., Nov. Ser. 67(109), 609--642 (1965; Zbl 0145.35202)] reads as follows. Let \(E_0, E, E_1\) be Banach spaces, \(E_0\subset E\subset E_1\), and the embedding \(E_0\) into \(E\) be compact. Then, for every \(\varepsilon>0\), there exists a constant \(c_{\varepsilon}\)
openaire   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Open problems in Banach spaces and measure theory

, 2016
We collect several open questions in Banach spaces, mostly related to measure theoretic aspects of the theory. The problems are divided into five categories: miscellaneous problems in Banach spaces (non-separable $L^p$ spaces, compactness in Banach ...
Rodriguez, Jose
core  

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Existence and Controls for Fractional Evolution Equations

Axioms
In this paper, we investigate the existence and uniqueness of mild solutions for non-autonomous fractional evolution equations (NFEEs) using the technique of non-compactness measure, focusing on scenarios where the semigroup is non-compact.
Ying Chen, Yong Zhou
doaj   +1 more source

Some perturbation results for ascent and descent via measure of non-compactness

Filomat, 2018
The aim of this paper is to enlarge some known results from Fredholm and perturbation theory via measure of non-compactness. As applications, we focus on the study of the essential ascent and the essential descent spectra of an operator T defined on a given Banach space. Some perturbation results are also investigated.
Chafai, Ezzeddine, Boumazgour, Mohamed
openaire   +2 more sources