Results 191 to 200 of about 14,437 (302)

Changes in flexibility but not in compactness underlie the thermal adaptation of prokaryotic adenylate kinases. [PDF]

Evol Lett
Kontopoulos DG, Patmanidis I, Barraclough TG, Pawar S.   +3 more
europepmc   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

The ICN-UN Battery: A Machine Learning-Optimized Tool for Expeditious Alzheimer's Disease Diagnosis. [PDF]

Diagnostics (Basel)
Barceló E, Romero D, Allegri R, Meza E, Mosquera-Heredia MI, Vidal OM, Silvera-Redondo C, Arcos-Burgos M, Garavito-Galofre P, Vélez JI.   +9 more
europepmc   +1 more source

Fixed Point and Common Fixed Point Results of \(D_F\)-Contractions via Measure of Non-compactness with Applications

, 2018
Asmat Ullah, Israr Ali Khan, Nayyar Mehmood   +2 more
openalex   +2 more sources

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

Employing Kuratowski measure of non-compactness for positive solutions of system of singular fractional q-differential equations with numerical effects

, 2020
Mohammad Esmael Samei
openalex   +2 more sources

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Structure-Guided Design of Novel Diarylpyrimidine-Based NNRTIs Through a Comprehensive In Silico Approach: 3D-QSAR, ADMET Evaluation, Molecular Docking, and Molecular Dynamics. [PDF]

Pharmaceuticals (Basel)
Baassi M, Moussaoui M, Rajkhowa S, Soufi H, Daoud R, Belaaouad S.   +5 more
europepmc   +1 more source

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

Molecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra, Lucca Paolo Hsu Helmich, Daniel Rodrigues de Bastos, Laura Sichero, Patrícia Savio de Araujo‐Souza, Fabio Passetti, Luisa Lina Villa   +6 more
wiley   +1 more source

Risk of genitourinary late effects after radiotherapy for prostate cancer associated with early changes in bladder shape. [PDF]

Phys Imaging Radiat Oncol
Casares-Magaz O, Raidou RG, Furmanová K, Pettersson N, Moiseenko V, Einck J, Hopper A, Knopp R, Muren LP.   +8 more
europepmc   +1 more source