Results 251 to 260 of about 14,437 (302)

SIRT4 positively regulates autophagy via ULK1, but independently of HDAC6 and OPA1

FEBS Open Bio, EarlyView.
Cells expressing SIRT4 (H161Y), a catalytically inactive mutant of the sirtuin SIRT4, fail to upregulate LC3B‐II and exhibit a reduced autophagic flux under stress conditions. Interestingly, SIRT4(H161Y) promotes phosphorylation of ULK1 at S638 and S758 that are associated with inhibition of autophagy initiation.
Isabell Lehmkuhl, Khawar Amin, Lydia Gabriel, Nils Hampel, Afshin Iram, Julia Hesse, Constanze Wiek, Jasmin Thuy Vy Nguyen, Helmut Hanenberg, Jürgen Scheller, M. Reza Ahmadian, Björn Stork, Doreen M. Floss, Roland P. Piekorz   +13 more
wiley   +1 more source

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

Tracking morphological development in stony corals

Fundakowski GJ, Brambilla V, Zawada KJA, Chow CFY, Croasdale E, Errington A, Fontoura L, Marais WJ, Woods RM, Edelaar P, Lala K, Madin JS, Dornelas M.   +12 more
europepmc   +1 more source

Adaptive fuzzy cluster-guided simple, fast, and efficient feature selection for high-dimensional and highly imbalanced binary-class bioinformatics microarray data. [PDF]

Sci Rep
Tye YW, Chew X, Yusof UK, Tulpar S.
europepmc   +1 more source

Engineering tandem VHHs to target different epitopes to enhance antibody‐dependent cell‐mediated cytotoxicity

FEBS Open Bio, EarlyView.
Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu, Hao Jiang, Limin Chen, Fulai Zhou, Ying Jin, Mark L. Chiu   +5 more
wiley   +1 more source

Morphometric analysis and weighted sum priority based prioritization of micro-watershed, kiltie watershed, Upper Blue Nile basin, Ethiopia. [PDF]

Sci Rep
Denekewu GA, Meshesha DT, Tsegaye EA.
europepmc   +1 more source

Identification of bioactive phytoconstituents as promising ABL2 inhibitors using virtual screening and molecular dynamics simulation. [PDF]

Sci Rep
Elayyan AEM, Elasbali AM, Alanazi MAM, Shamsi A, Mohammad T.   +4 more
europepmc   +1 more source

Multimodal investigation of dacomitinib-calf thymus DNA binding interaction: insights from spectroscopy, thermodynamics, and in-silico studies. [PDF]

RSC Adv
Alossaimi MA, Aldakhil T, Elmansi H, Belal F, Magdy G.   +4 more
europepmc   +1 more source

Matrix transformation and application of Hausdorff measure of non-compactness on newly defined Fibo-Pascal sequence spaces

Muhammet Cihat Dağlı, Taja Yaying
openalex   +2 more sources

Recycled aggregate size effect on shear and tensile fracture toughness of SCB Eco-friendly cemented specimens. [PDF]

Sci Rep
Dolatshahi A, Arash M, Molladavoodi H.
europepmc   +1 more source