Results 81 to 90 of about 14,437 (302)

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

Weighted fractional differential equations with infinite delay in Banach spaces

open access: yesOpen Mathematics, 2016
This paper is devoted to the study of fractional differential equations with Riemann-Liouville fractional derivatives and infinite delay in Banach spaces. The weighted delay is developed to deal with the case of non-zero initial value, which leads to the
Dong Qixiang, Liu Can, Fan Zhenbin
doaj   +1 more source

Effect of Cane Regulation and GA3 Spray on Berry Thinning in 'Thompson Seedless' Grape (Vitis vinifera L.)

open access: yesJournal of Horticultural Sciences, 2016
A field trial was conducted during 2013-14 and 2014-15 fruiting seasons in growers' vineyards around Nashik, Maharashtra, India to improve efficacy of GA3 sprays in berrythinning.
S D Shikhamany   +3 more
doaj   +1 more source

PICALM::MLLT10 translocated leukemia

open access: yesFEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen   +7 more
wiley   +1 more source

Solvability of m-product mixed non-linear functional integral equations

open access: yesBeni-Suef University Journal of Basic and Applied Sciences
The purpose of this paper is devoted to establishing the existence of solutions for m-product non-linear functional integral equations with weakly singular and Riemann–Liouville integral terms.
Amar Deep   +3 more
doaj   +1 more source

Applications of one inequality to measures of non-compactness and narrow operators [PDF]

open access: yesMathematical Inequalities & Applications, 2019
A version of the Dubinskii-Lions-Magenes inequality [\textit{Yu. A. Dubinskij}, Mat. Sb., Nov. Ser. 67(109), 609--642 (1965; Zbl 0145.35202)] reads as follows. Let \(E_0, E, E_1\) be Banach spaces, \(E_0\subset E\subset E_1\), and the embedding \(E_0\) into \(E\) be compact. Then, for every \(\varepsilon>0\), there exists a constant \(c_{\varepsilon}\)
openaire   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

open access: yesFEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan   +5 more
wiley   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

open access: yesFEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson   +7 more
wiley   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

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