Results 111 to 120 of about 4,562,823 (281)

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

The Computocene Era: Epistemological Machines and the Search for Algorithmic Fairness

Вестник Северного (Арктического) федерального университета: Серия «Гуманитарные и социальные науки»
In the context of total digital transformation, algorithms have ceased to be neutral data-processing tools, evolving into active architects of social interaction. This article provides a critical reflection on this shift within the Computocene era, where
Inga M. Zashikhina
doaj   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

An adaptive splicing method for panoramic images of deep well borehole walls based on YOLOv11s fused with structural similarity

Meitan xuebao
To achieve high-quality panoramic visualization of deep wellbore interior morphology and overcome the limitations of traditional image stitching methods in terms of automation, stitching quality, and processing efficiency, an intelligent image stitching ...
Di LIU, Zejia ZHANG, Caiwu LU, Qinghua GU, Song JIANG   +4 more
doaj   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Privacy-Preserving Profiling

, 2011
With the rise of social networking, and other sites which collect vast amounts of user data, the issue of user privacy has never been more important. When creating user profiles care must be taken to avoid collecting sensitive information, while ensuring
Barnard, Thomas, Prugel-Bennett, Adam
core   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Algebraic Models for Measure Preserving Transformations [PDF]

Transactions of the American Mathematical Society, 1968
Dinculeanu, Nicolae, Foiaș, Ciprian
openaire   +2 more sources

Optimized exposer region-based modified adaptive histogram equalization method for contrast enhancement in CXR imaging

Scientific Reports
In medical imaging, low-contrast chest X-ray (CXR) images may fail to provide adequate information for accurate visual interpretation and disease diagnosis.
Shivam Gangwar, Reeta Devi, Nor Ashidi Mat Isa   +2 more
doaj   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source