Results 231 to 240 of about 9,620,742 (295)

Mastering particle size analysis: lessons, challenges, and future directions from the FDA-CRCG workshop. [PDF]

AAPS Open
Xu X, Smith WC, Polli JE, Plavchak CL, Qin B, Wang Y, Holtgrewe N, Raney SG, O'Reilly Beringhs A, Yu YB, Taraban M, Krishnan V, Schwendeman A, Hammell DC, Clogston JD, Rawle AF, Grmaš J, Ayoub Y, Domnic B, Reddy RS, Duncan J, McGann M, Bodycomb J, Schuurmans CCL, Hermes M, Mehtala JG, Roy P, Lance K, Britten C, Park K, Beach D, Elmer M, Rodenhausen KB, Xu Z, Qu H, Wu KW, Korang-Yeboah M, Zou Y, Li J, Abuznait AH, Quinn C, Ethier A, Ip K, Dhamecha D, Li Q, Zhu D, Valapil R.   +46 more
europepmc   +1 more source

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

Outcome measurement instruments for the core outcome sets on genital gender-affirming surgery: the GenderCOS project. [PDF]

EClinicalMedicine
Angelini M, Roijer PJ, Vallinga MS, Pidgeon TE, Ceulemans A, Bakker A, Carrière B, Rashid T, Bellringer J, Belinky J, Buncamper M, Morrison SD, Bouman WP, van de Grift TC, Bouman MB, Mullender MG.   +15 more
europepmc   +1 more source

Engineering tandem VHHs to target different epitopes to enhance antibody‐dependent cell‐mediated cytotoxicity

FEBS Open Bio, EarlyView.
Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu, Hao Jiang, Limin Chen, Fulai Zhou, Ying Jin, Mark L. Chiu   +5 more
wiley   +1 more source

Cascade of Care for Opioid Use Disorder Among Medicaid Beneficiaries.

JAMA Netw Open
Lu TT, Dowd WN, Mark TL, Kluckman M, Montgomery BW, Katz C, DeLisle DE, Zarkin GA.   +7 more
europepmc   +1 more source

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source

In Primiparous Women at Term, a Symphysial Fundal Height of 36 cm Is Linked to the Lowest Risk of Emergency Caesarean Section and Postpartum Haemorrhage. [PDF]

Aust N Z J Obstet Gynaecol
Salmon JR, Jarrett A.
europepmc   +1 more source

Module Parasitics-Based Current and Temperature Sensing Using Explainable Neural Networks. [PDF]

Sensors (Basel)
Lautner F, Bakran MM.
europepmc   +1 more source