Results 61 to 70 of about 3,328,134 (337)

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Measurement Uncertainty Evaluation of Digital Modulation Quality Parameters: Magnitude Error and Phase Error

MATEC Web of Conferences, 2016
In digital modulation quality parameters traceability, the Error Vector Magnitude, Magnitude Error and Phase Error must be traced, and the measurement uncertainty of the above parameters needs to be assessed.
Zhan Zhiqiang, Xia Junwen, Wang Yunling, Yu Lei   +3 more
doaj   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

Repeatıbılıty Of Lateral Cephalometrıc Measurements And Dıgıtatıons

Turkish Journal of Orthodontics, 2004
The purpose of this study was determine the interexaminer tracing and digitizing repeatibility for computer aided lateral cephalometric measurements. The material used in this study comprised 60 lateral cephalometric radiograps (20 Class 1, 20 Class 2 ...
Alaattin Keykubat, Tuba ,Tortop-Üçem, Sema Yüksel, Cumhur Tuncer, Lale Taner   +4 more
doaj   +1 more source

EWMA Chart and Measurement Error [PDF]

Measurement error is a usually met distortion factor in real-world applications that influences the outcome of a process. In this paper, we examine the effect of measurement error on the ability of the EWMA control chart to detect out-of-control ...
Maravelakis, Petros, Panaretos, John, Psarakis, Stelios   +2 more
core   +1 more source

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source

Measurement errors in medical research

Payesh, 2010
To address research questions, measuring variables are neccessary. However, every measurement is prone to different types of measurement errors. Therefore, understanding about the different types of measurement errors are a great of importance This paper
Masumeh Sadeghi, Maryam Nasirian, Ali Akbar Haghdoost   +2 more
doaj  

Active Compensation Technology for the Target Measurement Error of Two-Axis Electro-Optical Measurement Equipment

Sensors
For two-axis electro-optical measurement equipment, there are many error sources in parts manufacturing, assembly, sensors, calibration, and so on, which cause some random errors in the final measurement results of the target.
Lintao Lan, Fangwu Hua, Fang Fang, Wei Jiang   +3 more
doaj   +1 more source