Results 131 to 140 of about 23,344,103 (371)

Substrate specificity of Burkholderia pseudomallei multidrug transporters is influenced by the hydrophilic patch in the substrate‐binding pocket

open access: yesFEBS Letters, EarlyView.
Multidrug transporters BpeB and BpeF from the Gram‐negative pathogen Burkholderia pseudomallei have a hydrophilic patch in their substrate‐binding pocket. Drug susceptibility tests and growth curve analyses using an Escherichia coli recombinant expression system revealed that the hydrophilic patches of BpeB and BpeF are involved in the substrate ...
Ui Okada, Satoshi Murakami
wiley   +1 more source

Aligning Capital With Mission: Lessons from the Annie E. Casey Foundation's Social Investment Program [PDF]

open access: yes, 2016
The Annie E. Casey Foundation engaged InSight at Pacific Community Ventures to conduct the first comprehensive third-party evaluation of the SI Program, with research support from the Center for the Advancement of Social Entrepreneurship (CASE) at Duke ...

core  

Function‐driven design of a surrogate interleukin‐2 receptor ligand

open access: yesFEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang   +9 more
wiley   +1 more source

Deep Learning Small Water Body Mapping by Transfer Learning from Sentinel-2 to PlanetScope

open access: yesRemote Sensing
Small water bodies are widely spread and play crucial roles in supporting regional agricultural and aquaculture activities. PlanetScope imagery has a high resolution (3 m) with daily global coverage and has obviously enhanced small water body mapping ...
Yuyang Li   +5 more
doaj   +1 more source

Balanced Scorecard in Serbia: management innovation or rhetoric game [PDF]

open access: yes
In performance measurement and management literature, the Balanced Scorecard is the most prominent model. It can be considered as effectiveness measurement, efficiency measurement or performance measurement model.
Bogicevic, Jasmina, Domanovic, Violeta
core   +1 more source

Crack propagation in light alloys Ministry of Aviation contract no. PD/28/07 [PDF]

open access: yes, 1965
The revised approach to the measurement of the rate of crack propagation in light alloys has entailed the development of new experimental techniques, in particular the development of a multi-channel interval timer.
Younger, A.
core  

Time after time – circadian clocks through the lens of oscillator theory

open access: yesFEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo   +2 more
wiley   +1 more source

The Value of Individual Screen Response Time in Predicting Student Test Performance: Evidence from TIMSS 2019 Problem Solving and Inquiry Tasks

open access: yesJournal of Intelligence
The time students spend on answering a test item (i.e., response time) and its relationship to performance can vary significantly from one item to another.
Bin Tan, Okan Bulut
doaj   +1 more source

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

open access: yesFEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf   +6 more
wiley   +1 more source

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