Results 271 to 280 of about 6,055,512 (371)

Cleavage‐Resistant CYLD Protects Against Autoimmune Hepatitis

Advanced Science, EarlyView.
Proteolytic cleavage of the deubiquitinase CYLD emerges as a critical driver of autoimmune hepatitis. TNFα‐induced CYLD loss in macrophages amplifies S100A9‐triggered MAPK activation, leading to excessive chemokine production and hepatic inflammation. Pharmacological inhibition of MEK signaling effectively attenuates experimental disease, highlighting ...
Han Liu, Chen Su, Jianling Liu, Mingyan Xing, Xiaoxia Wu, Lingxia Wang, Xiaoming Zhao, Hanwen Zhang, YangYang Xie, YangYang Wang, Hong Li, Yu Li, Ming Li, Haibing Zhang   +13 more
wiley   +1 more source

Psychometric validation of the SNAP-IV rating scale in amblyopic children at high AD/HD risk: structural validity and measurement invariance. [PDF]

Front Psychiatry
Pan L, Ru M, Huang Y, Luo W, Li L, Luo Y, Lin E, Kong M, Chen Q, Luo Y, Liu H, Huang S, Zeng J, Han F, Xiao X.   +14 more
europepmc   +1 more source

Personality in general and clinical samples: Measurement invariance of the Multidimensional Personality Questionnaire.

, 2016
Annemarie Eigenhuis, Jan H. Kamphuis, Arjen Noordhof   +2 more
openalex   +2 more sources

Identification and Characterization of an In Silico Designed Membrane‐Active Peptide with Antiviral Properties

Advanced Science, EarlyView.
An evolutionary molecular dynamics platform is used to design P1.6, a membrane‐active peptide that senses lipid packing defects in viral envelopes. P1.6 adopts a stabilized α‐helical structure upon membrane contact, disrupts virus‐like liposomes, and damages HIV‐1 particles.
Pascal von Maltitz, Niek van Hilten, Tatjana Weil, Thunchanok Thummaraj, Jeroen Methorst, Dennis Aschmann, Alexander Kros, Clarissa Read, Jasmina Gačanin, Herre Jelger Risselada, Jan Münch   +10 more
wiley   +1 more source

The Brief Lexington Attachment to Pets Scale: measurement invariance in India, Italy, Poland, and Russia. [PDF]

BMC Psychol
Nartova-Bochaver SK, Reznichenko SI, Larionow P, Ariccio S, Jankowski J, Kamble SV, Mosca O, Oziemblewska M, Patil AC, Scherba EK, Sołtys M, Johnson TP.   +11 more
europepmc   +1 more source

Mapping Charge Interactions in Intrinsically Disordered Proteins

Advanced Science, EarlyView.
This study presents analytical models to predict intrachain distances in intrinsically disordered proteins (IDPs), accounting for charge patterning, salt concentration, and electrostatic effects. Validated against single‐molecule FRET data, a minimal‐parameter polymer model is identified that captures key interactions and chain dimensions. These models
Michael Phillips, Andrea Holla, Magdalena Wojtas, Aritra Chowdhury, Andrea Sottini, Sebastian L. B. König, Natalie Mutter, Nick Lamb, Jonathan Huihui, Monika Lopko, Andrea Soranno, Daniel Nettels, Andrzej Ożyhar, Benjamin Schuler, Kingshuk Ghosh   +14 more
wiley   +1 more source

Measurement invariance and cross-linguistic validation of the PSS-4 in university context: multidimensional analysis and associations with psychological and behavioral outcomes. [PDF]

Front Psychol
Massé CC, Krieger V, Peró-Cebollero M, Amador-Campos JA, Guàrdia-Olmos J.   +4 more
europepmc   +1 more source

Irradiated Tumor Cell‐Derived Microparticles Activate Systemic Anti‐Tumor Immunity via the STING/NLRP3/GSDMD Axis in Neutrophils

Advanced Science, EarlyView.
Radiotherapy induces tumor cells to release microparticles (RT‐MPs) into the circulation. The mitochondrial DNA carried by these RT‐MPs activates the STING/NLRP3/GSDMD axis in splenic neutrophils, triggering IL‐1β secretion. This, in turn, enhances dendritic cell function and facilitates the formation of cytotoxic T lymphocytes, thereby promoting ...
Yan Hu, Jiacheng Wang, Mengjie Che, Zheng Yang, Jingshu Meng, Xiao Yang, Yue Deng, Zhiyuan Zhou, Yijun Wang, Wenwen Wei, Zhanjie Zhang, Bian Wu, You Qin, Kunyu Yang, Honglin Jin, Fang Huang, Yajie Sun, Lu Wen, Chao Wan   +18 more
wiley   +1 more source

Measurement invariance and differential item functioning of the positive and negative affect schedule: a psychometric study in Ecuadorian young adults. [PDF]

Front Psychol
Parra-Gaete C, Vinueza-Cabezas A, Bourgeat-Salazar M.   +2 more
europepmc   +1 more source

A Clarification on Quantum‐Metric‐Induced Nonlinear Transport

Advanced Science, EarlyView.
How does the quantum metric truly govern the nonlinear transport? The longstanding theoretical discrepancies are resolved in quantum‐metric‐induced nonlinear transport and the correct intrinsic nonlinear conductivity is identified. Furthermore, a toy model is engineered to suppress the competing effects, uniquely highlighting the role of quantum metric
Xiao‐Bin Qiang, Tianyu Liu, Zi‐Xuan Gao, Hai‐Zhou Lu, X. C. Xie   +4 more
wiley   +1 more source