Results 91 to 100 of about 178,977,434 (287)

Global Rather Than Vertical‐Selective Saccadic Abnormalities in Progressive Supranuclear Palsy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To test whether vertical saccades are preferentially affected in Progressive Supranuclear Palsy (PSP). Methods PSP patients (n = 24) were compared to age‐matched controls (n = 94) and two degenerative groups (Alzheimer's disease, n = 20; Lewy body disease, n = 50).
Duy Duan Nguyen, Mark Paine, Soohyun Lee, Amir Fazlollahi, Baibin (Ben) Wang, John D. O'Sullivan, Peter J. Nestor   +6 more
wiley   +1 more source

Re‐Purposing Sapropterin (Kuvan) for ACTA2‐Related Multisystemic Smooth Muscle Dysfunction Syndrome: A Translational Mechanistic and First‐In‐Human Therapeutic Report

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Multisystemic smooth muscle dysfunction syndrome (MSMDS) is an ultra‐rare, ACTA2‐related disorder characterized by severe cerebrovascular disease, aortic aneurysms, and smooth muscle dysfunction. Using molecular dynamics simulations and in silico drug screening, we identified that sapropterin dihydrochloride (Kuvan) is a candidate capable of ...
Moran Hausman‐Kedem, Noa Bielopolski, Vijai Krishnan, Shane Wald‐Altman, Shelly I Shrian, Omer Bar‐Yosef, Livia Kapusta, Claire Shamber, Patricia L. Musolino, Miguel Weil   +9 more
wiley   +1 more source

Evaluating a New Optical Device for Velocity-Based Training: Validity and Reliability of the PowerTrack^TM Sensor

Metrology
Background: Velocity-based training (VBT) requires precise measurement devices to monitor neuromuscular performance. PowerTrackTM is a novel optoelectronic device designed to assess movement velocity in resistance training.
Fernando Martin-Rivera, Darío Rodrigo-Mallorca, Luis M. Franco-Grau, Jose Vidal-Vidal, Angel Saez-Berlanga, Iván Chulvi-Medrano   +5 more
doaj   +1 more source

Troponin T and Neurofilament Light Chain Levels as Complementary Biomarkers of Disease Accumulation and Aggressiveness in Amyotrophic Lateral Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Amyotrophic lateral sclerosis (ALS) is a clinically heterogeneous neurodegenerative disease requiring reliable biomarkers to improve patient stratification and trial design. While serum neurofilament light chain (sNfL) reflects neuroaxonal stress and disease aggressiveness, troponin T (TnT) may capture complementary aspects of ...
Julia Sellin, Sofia Waldorf, Janina von der Gablentz, Torsten Grehl, Huelya Nazlican, Thomas Meyer, Julian Grosskreutz, Patrick Weydt, Sarah Bernsen   +8 more
wiley   +1 more source

Application of laser-based instrumentation for measurement of time-resolved temperature and velocity fields in the thermoacoustic system [PDF]

, 2010
This work aims to develop reliable laser-based measurement techniques to enable fundamental heat transfer and fluid flow studies in thermoacoustic systems.
Yu, Z., Jaworski, A.J., Shi, L., Yu, Zhibin, Yu, Z, Shi, L, Shi, Lei, Jaworski, Artur J, Jaworski, AJ   +8 more
core   +1 more source

High Speed Digital Video Capillaroscopy: Nailfold Capillary Shape Analysis and Red Blood Cell Velocity Measurement

Journal of Biomechanical Science and Engineering, 2007
Nailfold capillaroscopy has been shown to reflect microvascular disturbances mainly in connective tissue diseases, and the development of video capillaroscopy made it possible to determine capillary red blood cell velocity by measuring the displacement ...
Masao WATANABE, Mizuho MATSUBARA, Toshiyuki SANADA, Hiroaki KURODA, Masaki IRIBE, Masutaka FURUE   +5 more
doaj   +1 more source

Data‐Driven SuStaIn Model of Disability Progression in Amyotrophic Lateral Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To determine whether ordinal Subtype and Stage Inference (SuStaIn) applied to routine ALSFRS‐R item scores can identify reproducible disability progression patterns in amyotrophic lateral sclerosis (ALS) and provide clinically meaningful staging.
Giammarco Milella, Veria Vacchiano, Vittorio Velucci, Stefano Zoccolella, Rocco Liguori, Giovanni Defazio   +5 more
wiley   +1 more source

APPLICATION OF LASER FIBER OPTIC FOR BLOOD VELOCITY MEASURMENT

مجلة النهرين للعلوم الهندسية, 2009
The aim of this paper is to study the possibility of using laser technique for blood flow velocity measurement using the fiber optics to deliver the laser light and receive the scattered light from the blood flowing in different types of vessels.
Munqith S . Dawood, Anwaar A. Al-Dergazly, Sumia H. Jaafer   +2 more
doaj  

Association Between Neurofilament Light Chain and Real‐World Ambulatory Function in Progressive MS

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Neurofilament light chain (NfL) is a biomarker of neuroaxonal injury in multiple sclerosis (MS), yet associations with functional outcomes remain unclear. Longitudinal associations between serum NfL (sNfL) and daily step count (STEPS) from wearable devices were assessed in a large international progressive MS cohort.
Gabby B. Joseph, Megan McCune, Riley Bove, Ahmed Abdelhak, Bruce A. C. Cree, Valerie J. Block   +5 more
wiley   +1 more source

Experimental response of an optical sensor used to determine the moment of blast by sensing the flash of the explosion

South African Journal of Science, 2009
The Council for Scientific and Industrial Research (CSIR) conducts research into the effect of underwater explosions on maritime structures and equipment.
A. Roux, G.N. Nurick
doaj