Results 51 to 60 of about 675,335 (215)

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Does the quantum mechanical wave function exist?

Zagadnienia Filozoficzne w Nauce, 2019
I address the question whether the wave function in quantum theory exists as a real (ontic) quantity or not. For this purpose, I discuss the essentials of the quantum formalism and emphasize the central role of the superposition principle. I then explain
Claus Kiefer
doaj  

The Effect of Evaluating Self's Emotions on Frontal Alpha Asymmetry

Brain and Behavior
Purpose In research to assess emotions from biometric signals, participants are asked to evaluate the emotions they subjectively experienced to confirm whether the assumed emotions were actually elicited.
Masato Ito, Toru Takahashi, Yuto Kurihara, Rieko Osu   +3 more
doaj   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Hamiltonian tomography: the quantum (system) measurement problem

New Journal of Physics, 2015
To harness the power of controllable quantum systems for information processing or quantum simulation, it is essential to be able to accurately characterise the system's Hamiltonian.
Jared H Cole
doaj   +1 more source

Structured Oral Examinations in Internal Medicine - Case G

MedEdPORTAL, 2009
This resource is one component of the nine-part Structured Oral Examinations in Internal Medicine series. In this case (Case G: Asthma), a 45-year-old Saudi female teacher complains of recurrent breathlessness for the past 2 years, increasing to two to ...
Hani Almoallim, Ali Alkatheeri, Alaa Monjed, Fozya Basheer, Abdullah Tawakol, Ahmad Imam, Abdulalsalam Noorwali, Kamran Hameed   +7 more
doaj   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Deriving measurement collapse using zeta function regularisation and speculative measurement theory

Journal of Physics Communications
This paper shows how an application of zeta function regularisation to a physical model of quantum measurement yields a solution to the problem of wavefunction collapse.
Mark Stander
doaj   +1 more source

Structured Oral Examinations in Internal Medicine - Case I

MedEdPORTAL, 2009
This resource is one component of the nine-part Structured Oral Examinations in Internal Medicine series. In this case (Case I: Brain Abscess), a 50-year-old female is brought to the emergency room with complaints of fever, headache, and projectile ...
Hani Almoallim, Ali Alkatheeri, Alaa Monjed, Fozya Basheer, Abdullah Tawakol, Ahmad Imam, Abdulsalam Noorwali, Kamran Hameed   +7 more
doaj   +1 more source