Results 111 to 120 of about 3,405,509 (278)

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Measurement quantum mechanics and experiments on quantum Zeno effect

, 1995
Measurement quantum mechanics, the theory of a quantum system which undergoes a measurement process, is introduced by a loop of mathematical equivalencies connecting previously proposed approaches.
Onofrio, Roberto, Presilla, Carlo, Tambini, Ubaldo   +2 more
core   +1 more source

Measuring Property Rights Institutions

, 2020
How do the different elements in the standard bundle of property rights – such as the right of possession or the right of transfer – differentially impact outcomes, such as urban development? This paper incorporates insecure property rights into a standard model of urban land prices and density, and makes predictions about investment in land and ...
Simeon Djankov, Edward Glaeser, Valeria Perotti, Andrei Shleifer   +3 more
openaire   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Measurement properties of instruments measuring integrated care: a systematic review

International Journal of Integrated Care, 2014
Mary Ann Cruz Bautista, Milawaty Nurjono, Ezra Dessers, Yee Wei Lim, Hubertus Johannes Maria Vrijhoef   +4 more
doaj   +3 more sources

Electroweak measurements from $W$, $Z$ and photon final states

, 2014
We present the most recent precision electroweak measurements of single $W$ and $Z$ boson cross section and properties from the LHC and Tevatron colliders, analyzing data collected by ATLAS, CDF, CMS, D0, and LHCb detectors.
Yin, Hang
core   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Characterizing Quantum Properties of a Measurement Apparatus: Insights from the Retrodictive Approach

, 2010
Using the retrodictive approach of quantum physics, we show that the state retrodicted from the response of a measurement apparatus is a convenient tool to fully characterize its quantum properties.
A. M. Gleason, C. W. Helstrom, Claude Fabre, J. Von Neumann, J. A. Wheeler, Julien Laurat, N. Treps, S. Haroche, Taoufik Amri, U. Leonhardt   +9 more
core   +1 more source

Screening for lung cancer: A systematic review of overdiagnosis and its implications

Molecular Oncology, EarlyView.
Low‐dose computed tomography (CT) screening for lung cancer may increase overdiagnosis compared to no screening, though the risk is likely low versus chest X‐ray. Our review of 8 trials (84 660 participants) shows added costs. Further research with strict adherence to modern nodule management strategies may help determine the extent to which ...
Fiorella Karina Fernández‐Sáenz, Laura de la Torre‐Perez, David R Baldwin, Carlijn van der Aalst, Mangesh Thorat, David Ritchie, Andre L Carvalho, Carolina Espina, Ivan Solà, Carlos Canelo‐Aybar, Moira Magdalena Pissinis, Pablo Alonso‐Coello, Ana Carolina Pereira Nunes Pinto   +12 more
wiley   +1 more source

Blood rheological properties and methods of their measurement

Annales Academiae Medicae Silesiensis
From the physical point of view, blood is a multi-phase and multi-component system; plasma is the dispersion medium and the morphotic elements are the dispersed phase.
Tomasz Pryzwan, Patrycja Dolibog, Klaudia Kierszniok, Barbara Pietrzyk   +3 more
doaj   +1 more source