Results 71 to 80 of about 8,819,646 (297)

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

How should vaccine hesitancy be measured in healthcare workers? A systematic review of the measurement properties of validated tools

Human Vaccines & Immunotherapeutics
The use of validated tools to assess vaccine hesitancy is essential for designing strategies to improve vaccine uptake among healthcare workers (HCWs).
Erika Renzi, Nicolò Panattoni, Emanuele Di Simone, Marianna Riccio, Alessio Conti, Beatrice Albanesi, Michela Luciani, Diletta Fabrizi, Giulia Locatelli, Davide Ausili, Marco Clari, Corrado De Vito, Azzurra Massimi   +12 more
doaj   +1 more source

Review of the application of high temperature superconductors in coated conductor development and the measurement of their properties

, 2005
Since the 1960s, Nb-Ti, exhibiting a superconducting transition temperature Tc of 9K, and Nb3Sn, with a Tc of 18K have been the materials of choice for superconducting applications.
Bruneel, ElsWE068010009432800000-0002-6527-004XF4C6AE2E-F0ED-11E1-A9DE-61C894A0A6B4, Van Driessche, IsabelWE06WE51WE628010007010830000-0001-5253-3325F4614F2A-F0ED-11E1-A9DE-61C894A0A6B4, Penneman, Greet, Van Driessche, Isabel, Hoste, Serge, Hoste, SergeUGent801000316824972603757559F3AECC4C-F0ED-11E1-A9DE-61C894A0A6B4, Bruneel, Els, Schoofs, Bart8010017085706F8A37BC-B25E-11E6-B104-2D2FD0AF0289, Schoofs, Bart, Penneman, Greet80100150123472FD2896-B25E-11E6-B104-2D2FD0AF0289   +9 more
core  

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Effect of Spherical Indenter Radius on Hardness and Extraction Mechanical Property of RAFM Steel under Ion Irradiation

Yuanzineng kexue jishu, 2023
Currently, ion irradiation is commonly used to simulate neutron irradiation under specific conditions. Additionally, the nanoindentation testing system is extensively utilized for measuring the microscopic mechanical properties of materials that have ...
ZHOU Shanliang1;HUANG Xi1,*;ZHAO Qi1;ZHAN Zixiong1;LIAO Xinhua1;LIU Junxiong1;WEI Lihua2,3;LI Xiaoyan1
doaj   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Understanding Developmental Coordination Disorder in Youth Functioning: Measurement Properties of the Spanish Adolescents and Adults Coordination Questionnaire

Children
Background/Objectives: The Adolescent and Adult Coordination Questionnaire (AAC-Q) is a brief self-report tool developed to assess daily performance difficulties related to Criterion B of Developmental Coordination Disorder (DCD) across adolescence and ...
Laura Delgado-Lobete, Rebeca Montes-Montes, Nerea Blanco-Martínez, Rocío Carballo-Afonso, Carlos Ayán-Pérez   +4 more
doaj   +1 more source

Measurement Properties and Optimal Cutoff Point of the WHO-5 Among Chinese Healthcare Students

Psychology Research and Behavior Management, 2023
Nongnong Yang,1,* Haiyan Ma,1,2 Mengyi Huang,1,* Esther Yuet Ying Lau,3– 5 Daniel Yee Tak Fong,6 Meng Wang,7 Pengqiao Wang,1 Siyi Xu,8 Jiale Xu,1 Chen Jiang,1 Yi Luo,9 Runtang Meng1,2,* 1School of Public Health, Hangzhou Normal University ...
Yang N, Ma H, Huang M, Lau EYY, Fong DYT, Wang M, Wang P, Xu S, Xu J, Jiang C, Luo Y, Meng R   +11 more
doaj  

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source