Results 241 to 250 of about 5,211,328 (291)

Correlation of Gray-to-White matter ratio on Non-Contrast CT with neurological outcome in Post-Cardiac arrest syndrome. [PDF]

BMJ Neurol Open
El Mawla Z, Mulki J, Hassoun M, Aoude A.
europepmc   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Development of remote radar based vital sign acquisition for emergency department patient triage. [PDF]

Front Med Technol
Shaya Y, Levy G, Esterson A, Stein T, Kurtsman A, Czerniak H, Gordon I, Hod K, Halpern P, Zimilis S, West D, Trotzky D, Bublil I, Drescher MJ.   +13 more
europepmc   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Extracellular flux analyses indicate low ATP yield and require refinement for accurate determination of maximal oxygen consumption rate. [PDF]

Sci Rep
Ransy C, Boissan M, Hammad N, Bouaboud A, Issad T, De Dieuleveult M, Miotto B, Ye M, Pasmant E, Bouillaud F.   +9 more
europepmc   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Point-of-care-ultrasound measurements of cardiovascular indices across awake, sedated, anesthetized, and recovered states in dogs. [PDF]

Front Vet Sci
Warhoe J, Zersen KM, Cavanagh AA.
europepmc   +1 more source

Evaluation of artificial intelligence-based cephalometric analysis compared to the manual method. [PDF]

Prog Orthod
Alvarado-Lorenzo A, Criado-Pérez L, Garcovich D, Romero S, Scuzzo G, Scuzzo G, Curto A.   +6 more
europepmc   +1 more source