Results 161 to 170 of about 10,967,320 (288)

TRAMFIX: TRavelling Across Melbourne for FIXel-based analysis (a reproducibility and reliability study). [PDF]

Imaging Neurosci (Camb)
Mito R, Genc S, Halim J, Yang JY, Tournier JD, Kean M, Kokkinos C, McIntyre R, Di Biase MA, Smith RE, Zalesky A.   +10 more
europepmc   +1 more source

Detection of circulating tumor DNA in colorectal cancer patients using a methylation‐specific droplet digital PCR multiplex

Molecular Oncology, EarlyView.
We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto, Louise Raunkilde, Jan Lindebjerg, Mads Malik Aagaard, Christina Therkildsen, Jakob Kleif, Lars Henrik Jensen, Torben Frøstrup Hansen, Rikke Fredslund Andersen   +8 more
wiley   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Consensus on Subdomains and Measures of Relevance to Affective and Social Cognition Research on Bipolar Disorder (CAS-BD); Outcomes and Recommendations From an International Society for Bipolar Disorders Targeting Cognition Taskforce Study. [PDF]

Bipolar Disord
Van Rheenen TE, Lewandowski KE, Pinkham A, Varo C, Caruana G, Gruber J, Zarp J, Young AH, Yatham LN, Vieta E, Torres IJ, Tsapekos D, Sumiyoshi T, Stokes PRA, Schaffer A, Purdon S, Porter RJ, McIntyre RS, Martinez-Aran A, López-Jaramillo C, Lafer B, Kessing LV, Kjærstad HL, Hasler G, Gallagher P, Douglas K, Dols A, Carvalho AF, Burdick KE, Bowie CR, Bonnin CM, Balanzá-Martínez V, Miskowiak KW.   +32 more
europepmc   +1 more source

Next‐generation proteomics improves lung cancer risk prediction

Molecular Oncology, EarlyView.
This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj, Clara Frick, Ben Schöttker, Bernd Holleczek, Hermann Brenner   +4 more
wiley   +1 more source

Associations between maternal prepregnancy body mass index and maternal and cord blood metabolome. [PDF]

J Endocr Soc
Sormunen-Harju H, Girchenko PV, Kajantie E, Villa PM, Hämäläinen EK, Huvinen E, Lahti-Pulkkinen M, Laivuori H, Räikkönen K, Koivusalo SB.   +9 more
europepmc   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Remote outcome measures in Alzheimer's disease clinical trials: A call to action. [PDF]

J Prev Alzheimers Dis
Jimenez-Maggiora GA.
europepmc   +1 more source

Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib

Molecular Oncology, EarlyView.
WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute, Júlia Huguet‐Pradell, Jordi Abril‐Fornaguera, Albert Gris‐Oliver, Alex Rialdi, Elisa Fernández‐Martínez, Carla Montironi, Vanessa Del Pozo, Peter Houghton, Laura Zanatto, Agavni Mesropian, Ieva Keraite, Swan Thung, Carolina Armengol, Pau Sancho‐Bru, Ernesto Guccione, Roser Pinyol, Josep M. Llovet   +17 more
wiley   +1 more source

Adding home-use BIA scales, online food diaries, and tape-measures to large-scale questionnaire studies: Insights from the population-based PROFILES registry research. [PDF]

Support Care Cancer
Mols F, Ezendam NPM, Beijer S.
europepmc   +1 more source