Results 81 to 90 of about 1,449,134 (309)

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

Questionnaire choice affects the prevalence of recommended physical activity: an online survey comparing four measuring instruments within the same sample. [PDF]

BMC Public Health, 2021
Stassen G, Rudolf K, Gernert M, Thiel A, Schaller A.   +4 more
europepmc   +1 more source

Internal Consistency Reliability Of Instruments Measuring Students Satisfaction As An Internal Customer (Application Of Factor Analysis) [PDF]

, 2011
Reliability is consistency of the instrument in measurement whatever it measures. There are different methods available for estimating internal consistency reliability base on a single administration of a given assessment.
Gaguk , Margono
core  

Design and Content Validation of an Instrument Measuring User Perception of the Persuasive Design Principles in a Breastfeeding Mhealth App: A Modified Delphi Study

, 2022
Alaa Ali S. Almohanna, Khin Win, Shahla Meedya, Elena Vlahu‐Gjorgievska   +3 more
openalex   +1 more source

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

Parenting measures from the Family Life Questionnaire; parents and child psychopathological symptoms from the ASEBA instruments.

, 2020
Monica Bellina, Silvia Grazioli, Marco Garzitto, Maddalena Mauri, Eleonora Rosi, Massimo Molteni, Paolo Brambilla, Maria Nobile   +7 more
openalex   +1 more source

THE RELIABILITY OF AN INSTRUMENT TO MEASURE TEACHER KNOWLEDGE FROM THE PERSPECTIVE OF LEARNERS IN THE CONTEXT OF PIBID [PDF]

, 2018
Keysy Solange Costa Nogueira, Carmen Fernández   +1 more
openalex   +1 more source

The art of measuring art: Methodical development and validation of RizbA, a transdisciplinary rating instrument for two-dimensional pictorial works

, 2022
Kerstin Schoch
openalex   +1 more source

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

How blockchain impacts cloud-based system performance: a case study for a groupware communication application [PDF]

, 2019
This paper examines the performance trade-off when implementing a blockchain architecture for a cloud-based groupware communication application. We measure the additional cloud-based resources and performance costs of the overhead required to implement a
Beck, Roman, Eklund, Peter, Spasovski, Jason   +2 more
core   +1 more source