Results 241 to 250 of about 537,815 (299)

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Targeting p38α in cancer: challenges, opportunities, and emerging strategies

Molecular Oncology, EarlyView.
p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley   +1 more source

Electrical circuit model of spatiotemporal trade dynamics: Foundations and derivation of the gravity model. [PDF]

PLoS One
Robinson PA, McInnes A, Sajedianfard N, Melatos M, Henderson JA.   +4 more
europepmc   +1 more source

For good measure? A discourse analysis of social value in the UK nuclear decommissioning sector

, 2017
Mulholland, Cara, Chan, Paul W
openaire   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Industry-level estimates of export quality accounting for global value chains. [PDF]

Sci Data
Wacker KM, Ye X, Tusha D, Celani A.
europepmc   +1 more source

MF-YOLOv10: Research on the Improved YOLOv10 Intelligent Identification Algorithm for Goods. [PDF]

Sensors (Basel)
Wang Q, Wang X, Hou J, Liu X, Wen H, Ji Z.   +5 more
europepmc   +1 more source

Research on the coupling and coordination of harmonious rural construction and integration of agriculture and tourism. [PDF]

Sci Rep
Zhang W, Zhang L.
europepmc   +1 more source

Fairness and randomness in decision-making: the case of decision thresholds. [PDF]

Synthese
Vredenburgh K.
europepmc   +1 more source