Mutual control of cholinergic and low-threshold spike interneurons in the striatum [PDF]
Frontiers in Cellular Neuroscience, 2016 The striatum is the largest nucleus of the basal ganglia and is crucially involved in action selection and reward processing. Cortical and thalamic inputs to the striatum are processed by local networks in which several classes of interneurons play an ...
Rasha eElghaba +2 more
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Nicotine-Induced Effects on Nicotinic Acetylcholine Receptors (nAChRs), Ca2+ and Brain-Derived Neurotrophic Factor (BDNF) in STC-1 Cells. [PDF]
PLoS ONE, 2016 In addition to the T2R bitter taste receptors, neuronal nicotinic acetylcholine receptors (nAChRs) have recently been shown to be involved in the bitter taste transduction of nicotine, acetylcholine and ethanol.
Jie Qian +6 more
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First Evidence of Pharmaceutical Residues in the Cerrón Grande Reservoir, El Salvador [PDF]
MoleculesThis study presents a comprehensive evaluation and environmental risk assessment (ERA) of pharmaceutical residues in the Cerrón Grande Reservoir, one of the most important surface water bodies in El Salvador.
Irene Romero-Alfano +7 more
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Klotho microinjection into the RVLM attenuates acute kidney injury via interaction with the cholinergic anti-inflammatory pathway in rats [PDF]
Research in Pharmaceutical SciencesBackground and purpose: The Klotho (Klo) gene, an aging suppressor in rats, accelerates aging when disrupted and extends lifespan when overexpressed. It encodes a transmembrane protein primarily expressed in renal tubules.
Fatemeh Ahmadi +4 more
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Chronic exposure to cigarette smoke extract increases nicotine withdrawal symptoms in adult and adolescent male rats [PDF]
Advances in Drug and Alcohol Research, 2023 The aim of the current study was to determine whether non-nicotine constituents of cigarette smoke contribute to nicotine dependence in adolescent and adult male Sprague Dawley rats. For 10 days animals were given three times daily intravenous injections
Daisy D. Reynaga +3 more
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Ghrelin Amplifies the Nicotine-Induced Release of Dopamine in the Bed Nucleus of Stria Terminalis (BNST) [PDF]
Biomedicines, 2023 Ghrelin is an orexigenic neuropeptide that is known for stimulating the release of growth hormone (GH) and appetite. In addition, ghrelin has been implicated in addiction to drugs such as nicotine.
Jázmin Ayman +3 more
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Nicotinic Acetylcholine Receptor (nAChR) Dependent Chorda Tympani Taste Nerve Responses to Nicotine, Ethanol and Acetylcholine. [PDF]
PLoS ONE, 2015 Nicotine elicits bitter taste by activating TRPM5-dependent and TRPM5-independent but neuronal nAChR-dependent pathways. The nAChRs represent common targets at which acetylcholine, nicotine and ethanol functionally interact in the central nervous system.
Zuo Jun Ren +5 more
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Functional expression and properties of the tick α6 homomeric nicotinic acetylcholine receptor in Xenopus laevis oocytes [PDF]
Current Research in Parasitology and Vector-Borne DiseasesRecent studies have suggested that the tick Ixodes ricinus expresses nAChR subtypes which are activated by acetylcholine. Here, we investigated the potential of the Iricα6 subunit to form a functional receptor when expressed in Xenopus laevis oocytes ...
Alison Cartereau +3 more
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Nicotinic receptor modulation to treat alcohol and drug dependence [PDF]
Frontiers in Neuroscience, 2015 Alcohol and drug dependence are serious public health problems worldwide. The prevalence of alcohol and drug dependence in the United States and other parts of the world is significant.
Shafiqur eRahman +2 more
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Behavioral characterization of early nicotine withdrawal in the mouse: a potential model of acute dependence [PDF]
Behavioral and Brain FunctionsBackground Clinical and preclinical research have demonstrated that short-term exposure to nicotine during the initial experimentation stage can lead to early manifestation of withdrawal-like signs, indicating the state of “acute dependence”.
Baeksun Kim, Heh-In Im
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