Evaluation of novel epibatidine analogs in the rat nicotine drug discrimination assay and in the rat chronic constriction injury neuropathic pain model [PDF]
Advances in Drug and Alcohol Research, 2023 Nicotine is the primary psychoactive component responsible for maintaining tobacco dependence in humans. Chronic pain is often a consequence of tobacco-related pathologies, and the development of a dual therapeutic that could treat chronic pain and ...
Kevin Luque-Sanchez +8 more
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Reconsidering Ondansetron for Smoking Cessation: A Call for Renewed Investigation. [PDF]
Pharmacol Res PerspectPharmacology Research &Perspectives, Volume 13, Issue 6, December 2025.
Tam A, Munsar Z, Opler DJ.
europepmc +2 more sources
A tonic nicotinic brake controls spike timing in striatal spiny projection neurons
eLife, 2022 Striatal spiny projection neurons (SPNs) transform convergent excitatory corticostriatal inputs into an inhibitory signal that shapes basal ganglia output.
Lior Matityahu +7 more
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Cerebral Blood Flow Responses to Trigeminal Olfactory Stimulation and Their Nicotinic Cholinergic Regulation in Anesthetized Rats. [PDF]
Eur J NeurosciElectrical stimulation of the intranasal trigeminal nerves, which convey irritating odor information elevated blood flow in two brain areas, the olfactory bulb and the frontal cortex, with pressor response in anesthetized rats. After eliminating the pressor response, the intranasal stimulation increased blood flow only in the frontal cortex, and ...
Morihara D +3 more
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Single‐cell digital twins identify drug targets and repurposable medicine in Alzheimer’s disease [PDF]
Alzheimers DementAbstract Background Alzheimer’s disease (AD) is a complex and poorly understood neurodegenerative disorder with a lack of effective treatments. Novel approaches for identifying FDA‐approved drugs with potential for AD treatment hold promise to address this challenge.
Ren Y, Pieper A, Cummings J, Cheng F.
europepmc +2 more sources
Striatal Cholinergic Interneurons Control Physical Nicotine Withdrawal via Muscarinic Receptor Signaling. [PDF]
Adv Sci (Weinh)The role of striatal cholinergic interneurons in nicotine withdrawal is explored. Inhibition of striatal cholinergic interneurons (ChIs) ameliorated nicotine‐dependent alterations in striatal neural population activity, nicotine withdrawal‐induced deficit in striatal dopamine release, and physical nicotine withdrawal.
Kim B +7 more
europepmc +2 more sources
PLoS ONE, 2021 Cholinergic modulation of hippocampal network function is implicated in multiple behavioral and cognitive states. Activation of nicotinic and muscarinic acetylcholine receptors affects neuronal excitability, synaptic transmission and rhythmic ...
Olha Zapukhliak +7 more
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Brain and Behavior, 2020 Objectives There is a long‐standing interest in developing nicotinic acetylcholine receptor (nAChR) antagonists for concomitant use with nAChR agonists (e.g., nicotine replacement) as complementary smoking cessation aids.
Fernando B. deMoura +2 more
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Molecular Brain, 2022 Nicotinic acetylcholine receptors are thought to be associated with a wide range of phenomena, such as movement, learning, memory, attention, and addiction. However, the causal relationship between nicotinic receptor activity and behavior remains unclear.
Shohei Kaneko +5 more
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Pharmacological interventions on smoking cessation: A systematic review and network meta-analysis
Frontiers in Pharmacology, 2022 Objective: A network meta-analysis based on randomized controlled trials was conducted to investigate the effects of pharmacological interventions on smoking cessation.Methods: English databases were searched to obtain randomized controlled trials ...
Xue Shang +32 more
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