Results 31 to 40 of about 6,994 (188)

Activity-dependent modulation of layer 1 inhibitory neocortical circuits by acetylcholine [PDF]

, 2014
Layer 1 neocortical GABAergic interneurons control the excitability of pyramidal neurons through cell-class-specific direct inhibitory and disynaptic disinhibitory circuitry.
Brombas, Arne, Fletcher, Lee N., Williams, Stephen R.   +2 more
core   +1 more source

Nicotine addiction : a review [PDF]

, 2013
Nicotine, the major psychoactive compound in tobacco, acts as a potent addictive drug in humans. The addictive nature of nicotine leads to more than 6 million deaths a year.
Di Giovanni, Giuseppe, Vella, Jacob
core   +1 more source

The role of spinal adrenergic receptors on the antinociception of ginsenosides in a rat postoperative pain model [PDF]

Korean Journal of Anesthesiology, 2013
BackgroundThe effect of spinal adrenergic and cholinergic receptors on the anti-nociceptive effect of intrathecal ginsenosides was determined in a rat postoperative pain model.MethodsCatheters were placed into the intrathecal space of male Sprague-Dawley
In Ji Kim, Cheon Hee Park, Seong Heon Lee, Myung Ha Yoon   +3 more
doaj   +1 more source

Nicotinic acetylcholine receptors modulate osteoclastogenesis [PDF]

, 2016
Background: Our aim was to investigate the role of nicotinic acetylcholine receptors (nAChRs) in in-vitro osteoclastogenesis and in in-vivo bone homeostasis.
A Bajayo, A Orr-Urtreger, A Yarilina, AJ Ewins, Attila Mócsai, CL Henemyre, David Győri, DE Rothem, Despoina Sykoutri, DK Williams, E Somm, EX Albuquerque, FC Macintosh, Gyula Poór, H Takayanagi, H Tanaka, H Tanaka, I Wessler, J Tam, JA Dani, Josef S. Smolen, K Kawashima, K Kliemann, K Redlich, KJ Tracey, KS Lips, Kurt Redlich, LM Koval, LM Walker, LZ Wu, M Artico, M Asagiri, M En-Nosse, M Kedmi, M Rosas-Ballina, MA Fang, MA Maanen van, MR McClung, MR Picciotto, O Herault, PC Staton, Peter Mandl, Petra Scholze, R Reitstetter, RL Papke, S Hayer, S Yuhara, SB Cohen, Sigismund Huck, Silvia Hayer, SJ Romano, Stephan Blüml, T Koga, T Negishi-Koga, T Sato, Thomas Karonitsch, V Itier, ZQ Wang   +57 more
core   +2 more sources

A Two-Day Continuous Nicotine Infusion Is Sufficient to Demonstrate Nicotine Withdrawal in Rats as Measured Using Intracranial Self-Stimulation.

PLoS ONE, 2015
Avoidance of the negative affective (emotional) symptoms of nicotine withdrawal (e.g., anhedonia, anxiety) contributes to tobacco addiction. Establishing the minimal nicotine exposure conditions required to demonstrate negative affective withdrawal signs
Peter Muelken, Clare E Schmidt, David Shelley, Laura Tally, Andrew C Harris   +4 more
doaj   +1 more source

Topical Mecamylamine for Diabetic Macular Edema [PDF]

American Journal of Ophthalmology, 2010
Stimulation of nicotinic acetylcholine (nACh) receptors on vascular endothelial cells promotes angiogenesis and vascular permeability in animal models. The safety and bioactivity of topical mecamylamine, an antagonist of nACh receptors, was tested in patients with diabetic macular edema.A multicenter phase I/II clinical trial.Twenty-three patients with
Peter A, Campochiaro, Syed Mahmood, Shah, Gulnar, Hafiz, Jeffery S, Heier, Eugene S, Lit, Ingrid, Zimmer-Galler, Roomasa, Channa, Quan Dong, Nguyen, Beena, Syed, Diana V, Do, Lili, Lu, James, Monk, John P, Cooke, M Ken, Kengatharan, Henry H, Hsu   +14 more
openaire   +2 more sources

Critical Role of CA1 Nicotinic Receptors on Memory Acquisition Deficit Under Induction of Total Sleep Deprivation and REM Sleep Deprivation

International Clinical Neuroscience Journal, 2018
Background: Sleep disorder or sleep deprivation (SD) is a common issue in today’s society. Numerous evidences show that sleep is essential for proper brain performance and cognitive processes; on the other hand, cognitive functions have a broad range ...
Bibi-Zahra Javad-Moosavi, Gholamhassan Vaezi, Mohammad Nasehi, Seyed-Ali Haeri-Rouhani, Mohammad-Reza Zarrindast   +4 more
doaj   +1 more source

TLR2 and TLR4 Modulate Mouse Ileal Motility by the Interaction with Muscarinic and Nicotinic Receptors

Cells, 2022
Irritable bowel syndrome (IBS) is a chronic functional bowel disorder characterized by intestinal dysmotility. Changes in intestinal microbiota (dysbiosis) can lead to alterations in neuro-muscular functions in the gut. Toll-like receptors (TLRs) 2 and 4
Elena Layunta, Raquel Forcén, Laura Grasa   +2 more
doaj   +1 more source

Effect of α7 nicotinic acetylcholine receptor activation on cardiac fibroblasts: A mechanism underlying RV fibrosis associated with cigarette smoke exposure [PDF]

, 2017
INTRODUCTION: Right ventricular dysfunction is associated with numerous smoking-related illnesses including chronic obstructive pulmonary disease (COPD) where it is present even in absence of pulmonary hypertension. It is unknown if exposure to cigarette
Allawzi, Ayed, Chichger, Havovi, Choudhary, Gaurav, Clements, Richard T., Dudley, Samuel C. Jr., Jeong, Euy-Myoung, Kue, Nouaying, Lu, Qing, O'Connell, Kelly, Rounds, Sharon, Sakhatskyy, Pavlo, Vang, Alexander, Zhang, Peng   +12 more
core   +1 more source

Photoactivatable drugs for nicotinic optopharmacology [PDF]

, 2018
Photoactivatable pharmacological agents have revolutionized neuroscience, but the palette of available compounds is limited. We describe a general method for caging tertiary amines by using a stable quaternary ammonium linkage that elicits a red shift in
A Nadler, AM Sarker, Anis Contractor, C Herbivo, C Xu, Can Peng, David L Wokosin, EJ Petersson, GC Ellis-Davies, Guiqing Zhao, H Taniguchi, Henry A Lester, HJ Motulsky, J Michael McIntosh, J Mütze, J Ren, J Rossi, J Schaal, JB Grimm, JB Grimm, John J Macklin, John J Marshall, Kyle R Gee, L Azam, L Azam, L Khiroug, L Madisen, Luke D Lavis, M Matsuzaki, M Matsuzaki, Matthew C Arvin, MJ Davis, N Asad, Nicholas M Bannon, NS Makarov, O Filevich, PY Shih, PY Shih, R Salas, R Zhao-Shea, Ryan M Drenan, Sambashiva Banala, SE Engle, ST McCarron, T Furuta, TA Pologruto, TW Chen, V Hagen, V Hagen, V Parikh, Veronica J Kim, VR Shembekar, Xiao-Tao Jin, Yevgenia Kozorovitskiy, Yong Wang   +54 more
core   +1 more source