Results 51 to 60 of about 6,994 (188)
ToxicsAcute intoxication with organophosphorus (OP) cholinesterase inhibitors can produce seizures that rapidly progress to life-threatening status epilepticus.
Peter M. Andrew +10 more
doaj +1 more source
Journal of Parkinson’s Disease, 2013 Background: Parkinson's disease (PD) is associated with neurodegeneration of dopaminergic neurons and an accompanying neuroinflammatory process in the substantia nigra (SN).
Vanessa Stuckenholz +6 more
doaj +1 more source
Cholinergic regulation of mood: from basic and clinical studies to emerging therapeutics. [PDF]
, 2019 Mood disorders are highly prevalent and are the leading cause of disability worldwide. The neurobiological mechanisms underlying depression remain poorly understood, although theories regarding dysfunction within various neurotransmitter systems have ...
Dulawa, Stephanie C, Janowsky, David S
core
Searching for New Leads to Treat Epilepsy: Target-Based Virtual Screening for the Discovery of Anticonvulsant Agents [PDF]
, 2018 The purpose of this investigation is to contribute to the development of new anticonvulsant drugs to treat patients with refractory epilepsy. We applied a virtual screening protocol that involved the search into molecular databases of new compounds and ...
Bruno Blanch, Luis Enrique +8 more
core +2 more sources
Engaging Gut‐to‐Brain Signalling to Treat Alcohol Use Disorder
Addiction Biology, Volume 31, Issue 3, March 2026.ABSTRACT According to the 2023 National Survey on Drug Use and Health (NSDUH), 28.9 million people ages 12 and older in the United States had alcohol use disorder (AUD) in the past year. Although chronic alcohol use contributes to numerous health disorders as well as being an economic burden, there are few medications approved for treatment of AUD, and
Paula L. Hoffman +15 more
wiley +1 more source
Journal of Pharmacological Sciences, 2010 Although a blockade of acetylcholine esterase has been reported to suppress neuronal cell death induced by exogenous glutamate and β-amyloid, information is still limited regarding the neuroprotective effects of the acetylcholine esterase inhibitor ...
Kenji Sakamoto +4 more
doaj +1 more source
In Search of the Neurobiological Substrates for Social Playfulness in Mammalian Brains
, 2011 Play behavior is a fundamental and intrinsic neurobehavioral process in the mammalian brain. Using rough-and-tumble play in the juvenile rat as a model system to study mammalian playfulness, some of the relevant neurobiological substrates for this ...
Panksepp, Jaak, Siviy, Stephen M.
core +1 more source
Sympathetic-correlated c-Fos expression in the neonatal rat spinal cord in vitro [PDF]
, 2009 An isolated thoracic spinal cord of the neonatal rat in vitro spontaneously generates sympathetic nerve discharge (SND) at ~25°C, but it fails in SND genesis at ≤ 10°C.
Chun-Kuei Su +4 more
core +2 more sources
Alcohol, Clinical and Experimental Research, Volume 50, Issue 2, February 2026.This review highlights the biphasic sipper model pioneered by Dr. Hank Samson's laboratory, which separates appetitive and consummatory behaviors in rodent ethanol self‐administration. Over two decades of research using this paradigm reveals that alcohol‐directed behaviors are dynamic, shaped by internal states, cues, and experience.
Olivia A. Colarusso, Jeffrey L. Weiner
wiley +1 more source
Frontiers in Immunology, 2019 Type I diabetes (T1D) is a T cell-driven autoimmune disease that results in the killing of pancreatic β-cells and, consequently, loss of insulin production.
Maria J. Fernández-Cabezudo +9 more
doaj +1 more source