Results 71 to 80 of about 6,994 (188)

Differential Expression and Function of Nicotinic Acetylcholine Receptors in Subdivisions of Medial Habenula [PDF]

, 2014
Neuronal nAChRs in the medial habenula (MHb) to the interpeduncular nucleus (IPN) pathway are key mediators of nicotine's aversive properties. In this paper, we report new details regarding nAChR anatomical localization and function in MHb and IPN. A new
Deshpande, Purnima, Drenan, Ryan M., Engle, Staci E., Lester, Henry A., Oh, Gyeon, Puskar, Nyssa L., Shih, Pei-Yu   +6 more
core   +1 more source

Running away from addiction: Exercise, smoking cessation and neuroscience

Tobacco Prevention and Cessation, 2018
Background and purpose There is substantial evidence to suggest that exercise decreases nicotine withdrawal symptoms in humans; however, the mechanism mediating this effect is unclear. Here we investigate in a mouse model the effect of exercise intensity
Alexis Bailey, H Keyworth, James Lind, Andria Tzaikouri, Andre Veloso Rueda, Ying Chen, Ian Kitchen, Rosana Camarini, Mark Cropley   +8 more
doaj   +1 more source

Role of noradrenergic transmission within the ventral bed nucleus of the stria terminalis in nicotine withdrawal‐induced aversive behavior

Neuropsychopharmacology Reports, 2022
Aim Cessation of smoking induces nicotine withdrawal symptoms such as anxiety, depression, and dysphoria, which could lead to smoking relapse. In the present study, we examined the role of noradrenergic transmission within the ventral bed nucleus of the ...
Saya Arakaki, Masabumi Minami
doaj   +1 more source

Representation learning of drug and disease terms for drug repositioning

, 2017
Drug repositioning (DR) refers to identification of novel indications for the approved drugs. The requirement of huge investment of time as well as money and risk of failure in clinical trials have led to surge in interest in drug repositioning.
Anand, Ashish, Manchanda, Sahil
core   +1 more source

Wheel running during chronic nicotine exposure is protective against mecamylamine‐precipitated withdrawal and up‐regulates hippocampal α7 nACh receptors in mice [PDF]

, 2017
Background and purpose Evidence suggests that exercise decreases nicotine withdrawal symptoms in humans; however, the mechanisms mediating this effect are unclear.
Abrantes, al'Absi, Alexander, Alexander, Aydin, Baldwin, Balter, Barik, Berrendero, Breese, Brunzell, Castañé, Christensen, Cippitelli, Cosgrove, Curtis, Czubak, Dajas-Bailador, Damaj, Dubreucq, Erickson, Field, Fisher, Fuss, Georgiou, Haasova, Hadjiconstantinou, Hambsch, Harmey, Hasan, Ickes, Jackson, Jackson, Kenny, Kilkenny, Krishnan-Sarin, Li, Lifestyles Statistics Team, The Health and Social Care Information Centre, Malin, Marubio, Massey, Matta, McGinty, McGrath, Merrer, Metaxas, Miladi-Gorji, Mineur, Oliveira, Parrott, Picciotto, Picciotto, Rankin, Raybuck, Rueda, Salas, Salas, Sanchez, Scerbo, Scott, Simmons, Smith, Southan, Stoker, Strickland, Tapia-Arancibia, Taylor, Taylor, Thanos, Ussher, Vučcković, Walters, Wilkinson, Wright, Zanos, Zhou   +75 more
core   +1 more source

Cannabinoid CB2 receptor‐mediated analgesia: mechanism‐based insights and therapeutic potential

British Journal of Pharmacology, Volume 182, Issue 21, Page 5090-5118, November 2025.
Agonists of the cannabinoid 2 (CB2) receptor have shown promise for the treatment of pain in a variety of animal models. However, despite current preclinical evidence supporting the use of CB2 agonists for pain, successful translation of findings from preclinical models to human patients is lacking.
Kelsey G. Guenther, Andrea G. Hohmann
wiley   +1 more source

Characterization of nAChRs in Nematostella vectensis supports neuronal and non-neuronal roles in the cnidarian–bilaterian common ancestor

EvoDevo, 2019
Background Nicotinic and muscarinic acetylcholine receptors likely evolved in the cnidarian–bilaterian common ancestor. Both receptor families are best known for their role at chemical synapses in bilaterian animals, but they also have described roles as
Dylan Z. Faltine-Gonzalez, Michael J. Layden   +1 more
doaj   +1 more source

Selective and regulated trapping of nicotinic receptor weak base ligands and relevance to smoking cessation [PDF]

, 2017
© The Author(s), 2017. This article is distributed under the terms of the Creative Commons Attribution License. The definitive version was published in eLife 6 (2017): e25651, doi:10.7554/eLife.25651.To better understand smoking cessation, we examined ...
Govind, Anitha P., Green, William N., Stolz, Jacob R., Swanson, Geoffrey T., Vallejo, Yolanda F., Yan, Jing-Zhi   +5 more
core   +1 more source

ACSL6 Is Associated with the Number of Cigarettes Smoked and Its Expression Is Altered by Chronic Nicotine Exposure [PDF]

, 2011
Individuals with schizophrenia tend to be heavy smokers and are at high risk for tobacco dependence. However, the nature of the comorbidity is not entirely clear.
Aggen, Steven H., Anton, Raymond, Brunzell, Darlene H., Chen, Jingchun, Chen, Xiangning, Damaj, Imad, Farrer, Lindsay A., Gejman, Pablo, Gelemter, Joel, Holmans, Peter, Jackson, Kia J., Kendler, Kenneth S., Kranzler, Henry R., Kuo, Po-Hsiu, Levinson, Douglas F., Li, Minf D., Ma, Jennie Z., Payne, Thomas J., Sherva, Richard, van der Vaart, Andrew, Webb, Bradley T.   +20 more
core   +1 more source

Protective Activity of Melatonin Combinations and Melatonin‐Based Hybrid Molecules in Neurodegenerative Diseases

Journal of Pineal Research, Volume 76, Issue 8, November 2024.
ABSTRACT The identification of protective agents for the treatment of neurodegenerative diseases is the mainstay therapeutic goal to modify the disease course and arrest the irreversible disability progression. Pharmacological therapies synergistically targeting multiple pathogenic pathways, including oxidative stress, mitochondrial dysfunction, and ...
Francesca Galvani, Mariarosaria Cammarota, Federica Vacondio, Silvia Rivara, Francesca Boscia   +4 more
wiley   +1 more source