Allosteric Regulation of RNA Affinity by Motif V‐VI Coupling in West Nile Virus NS3 Helicase
ABSTRACT The rise of flaviviral diseases, including West Nile virus (WNV), presents a growing threat to global public health and underscores the urgent need for new therapeutic strategies. The non‐structural protein 3 helicase (NS3h) of the Orthoflavivirus genus, including WNV, is essential for viral replication and a promising antiviral target ...
Priti Roy, Martin McCullagh
wiley +1 more source
Transthoracic Echocardiography in Assessing Patients with Suspected Infective Endocarditis (TEASE): An Exploratory Study. [PDF]
Cambise N +19 more
europepmc +1 more source
Betulin Protects Against Cardiac Hypertrophy by Improving AMPK/Nrf2‐Dependent Mitochondrial Function
Betulin effectively mitigates pressure overload‐induced cardiac hypertrophy in both Ang II‐infused and TAC‐operated mice. Mechanistically, betulin activated AMPK phosphorylation, promoted Nrf2 nuclear translocation, and upregulated antioxidant genes (HO‐1 and NQO‐1), thereby restoring mitochondrial function in cardiomyocytes.
Bei Zheng +8 more
wiley +1 more source
Marfan Syndrome Associated With Acute Myocardial Infarction in the First Trimester of Pregnancy. [PDF]
Korkontzelos I +7 more
europepmc +1 more source
Deep Reinforcement Learning‐Based Control for Real‐Time Hybrid Simulation of Civil Structures
ABSTRACT Real‐time Hybrid Simulation (RTHS) is a cyber‐physical technique that studies the dynamic behavior of a system by combining physical and numerical components that are coupled through a boundary condition enforcer. In structural engineering, the numerical components are subjected to environmental loads that become dynamic displacements of the ...
Andrés Felipe Niño +6 more
wiley +1 more source
Ventricular assist device implantation in children with a mechanical valve: An ACTION registry analysis. [PDF]
Hussain SF +19 more
europepmc +1 more source
ABSTRACT Collaborative operation of multiple autonomous underwater vehicles (AUVs) can effectively achieve scientific goals that are hard to achieve by independently operated vehicles. Some science payloads are large, expensive, and need to be installed in the vehicle's nose cone. A vehicle can only carry one such payload.
Yanwu Zhang +9 more
wiley +1 more source
Prognostic significance of fibrinogen levels in sepsis-associated acute kidney injury: unveiling a nonlinear relationship and clinical implications. [PDF]
Chen M +7 more
europepmc +1 more source
Connecticut Construction Industries Association, Inc. (Heavy and Highway) and International Union of Operating Engineers (IUOE), AFL-CIO, Local 478 (2002) [PDF]
core +1 more source
ABSTRACT Sustainable weed management necessitates herbicide‐reduced, precision weed control. Recent advancements in machine vision and artificial intelligence (AI) for weed recognition and localization have created new opportunities for high‐precision weeding. Although blanket spraying systems are widely used for weed removal, machine vision‐guided, AI‐
Boyang Deng, Yuzhen Lu, Daniel Brainard
wiley +1 more source

