Results 121 to 130 of about 1,395,295 (247)

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

open access: yesMolecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He   +8 more
wiley   +1 more source

A review on multicomponent rare earth silicate environmental barrier coatings

open access: yesJournal of Materials Research and Technology
Rare earth (RE) silicate environmental barrier coatings (EBCs), with superior physicochemical properties and resistance to hot water-oxygen and calcium-magnesium-aluminosilicate (CMAS) corrosion, are ideal candidates for safeguarding the next-generation ...
Bin Qian   +5 more
doaj   +1 more source

Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA

open access: yesMolecular Oncology, EarlyView.
Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson   +2 more
wiley   +1 more source

Simultaneous enhancement of mechanical properties at room and elevated temperatures in Mg-RE alloy via twin-induced recrystallization and LPSO precipitation

open access: yesJournal of Materials Research and Technology
Understanding the microstructure evolution of long period stacking ordered (LPSO) phases in deformation-twinned Mg-RE alloys and its impact on mechanical performance remains limited.
Jiawen Zhou   +5 more
doaj   +1 more source

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

open access: yesMolecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia   +9 more
wiley   +1 more source

Harnessing Bifunctional Nitrogen‐Dislocation Interactions for a Record Ultra‐Strong‐and‐Ductile Duplex Titanium Alloy

open access: yesAdvanced Science
Duplex (α+β) Ti alloys often manifest limited uniform elongation (εu) mainly originating from the lack of dislocations for insufficient work hardening capability and semi‐coherent α/β interfaces for strain incompatibility.
Chongle Zhang   +5 more
doaj   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

open access: yesMolecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed   +10 more
wiley   +1 more source

A knowledge‐based materials descriptor for compositional dependence of phase transformation in NiTi shape memory alloys

open access: yesMaterials Genome Engineering Advances
This study presents ∆τ, a novel descriptor that captures the compositional dependence of phase transformation temperature (Ap) in NiTi‐based shape memory alloys (SMAs).
Cheng Li   +3 more
doaj   +1 more source

Thermal damage behavior and material removal mechanism during femtosecond and nanosecond laser ablation of refractory metal molybdenum

open access: yesJournal of Materials Research and Technology
This study focused on contrasting the thermal damage and material removal mechanisms of the refractory metal molybdenum in ablation processes generated by short-pulse lasers(nanosecond) and ultra-short-pulse(femtosecond) lasers.
Jie Ning   +4 more
doaj   +1 more source

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