Results 131 to 140 of about 12,483,612 (316)

Emergent mechanical control of vascular morphogenesis. [PDF]

Sci Adv, 2023
Whisler J, Shahreza S, Schlegelmilch K, Ege N, Javanmardi Y, Malandrino A, Agrawal A, Fantin A, Serwinski B, Azizgolshani H, Park C, Shone V, Demuren OO, Del Rosario A, Butty VL, Holroyd N, Domart MC, Hooper S, Szita N, Boyer LA, Walker-Samuel S, Djordjevic B, Sheridan GK, Collinson L, Calvo F, Ruhrberg C, Sahai E, Kamm R, Moeendarbary E.   +28 more
europepmc   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Topology and flywheel size optimization for mechanical hybrid powertrains

, 2014
Mechanical hybrid powertrains have the potential to improve the fuel economy of passenger vehicles at a relatively low cost, by adding a flywheel and only mechanical transmission components to a conventional powertrain.
Rullens, Sander, Steinbuch, M Maarten, Hofman, T., Rullens, SCA, Steinbuch, M., Vroemen, BG Bas, Hofman, T Theo, Vroemen, B., Berkel, K Koos van, van Berkel, K., Hofman, T.; id_orcid, Steinbuch, M.; id_orcid   +11 more
core   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Mechanical control of neural plate folding by apical domain alteration. [PDF]

Nat Commun, 2023
Matsuda M, Rozman J, Ostvar S, Kasza KE, Sokol SY.   +4 more
europepmc   +1 more source

Elements of Mechanical Design

, 2010
Examination and practice in the application of many mechanical design elements, including control components. Students working in groups design, fabricate, and test prototype devices in response to requests from industrial sponsors.
Smith, Amy, Frey, Daniel
core  

Finite Element Analysis of an Electro-Mechanical Knee Loading Device

, 2016
The mechanical loading of knee is an effective regimen for treatment of bone related ailments like fractures, osteoarthritis, and osteoporosis [1–2]. Efficacy of knee loading is evident from the previous studies done on rodents and other small animals [3]
Sai Krishna Prabhala, Chien, Stanley, Yokota, Hiroki, Hiroki Yokota, Sohel Anwar, Stanley Chien, Prabhala, Sai Krishna, Anwar, Sohel   +7 more
core   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Design and Optimization Analysis of an Adaptive Knee Exoskeleton

Chinese Journal of Mechanical Engineering
To solve the problem of undesired relative motion of human-machine interaction positions caused by misalignment of the human-machine joints rotation axis of the knee exoskeleton, this study designed an adaptive knee exoskeleton based on a gear-link ...
Xinhua Yang, Sheng Guo, Peiyi Wang, Yifan Wu, Lianzheng Niu, Duxin Liu   +5 more
doaj   +1 more source