Results 71 to 80 of about 11,952,015 (299)

Optimization aided Loop Shaping for Motion Systems [PDF]

, 2006
An approach is proposed which improves the quality and speed of manual loop shaping. Loop shaping is an iterative and creative controller design procedure where the control engineer uses frequency response function (FRF) data of the plant to shape the ...
Steinbuch, M Maarten, Bruijnen, DJH Dennis, Steinbuch, M., Rene De Molengraft, Rene van de Molengraft, Bruijnen, D.J.H., Molengraft, MJG René van de, Molengraft, van de, M.J.G., Maarten Steinbuch, Molengraft, van de, M.J.G.; id_orcid, Dennis Bruijnen, Steinbuch, M.; id_orcid   +11 more
core   +2 more sources

A MEMS electro-mechanical co-optimization platform featuring freeform geometry optimization based on a genetic algorithm

Microsystems & Nanoengineering
This paper describes a novel, system-level design methodology based on a genetic algorithm (GA) using freeform geometries for microelectromechanical systems (MEMS) devices.
Chen Wang, Xinyu Wu, Sina Sadeghpour, Milad Shojaeian, Linlin Wang, Bernardo Pereira Madeira, Yangyang Guan, Huafeng Liu, Yuan Wang, Pan Zhang, Pui-in Mak   +10 more
doaj   +1 more source

Identification of the unstable human postural control system

Frontiers in Systems Neuroscience, 2016
Maintaining upright bipedal posture requires a control system that continually adapts to changing environmental conditions, such as different support surfaces.
Sungjae eHwang, Peter eAgada, Tim eKiemel, John J Jeka, John J Jeka   +4 more
doaj   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source

Loop B is a major structural component of the 5-HT3 receptor [PDF]

, 2008
The 5-HT3 receptor belongs to a family of therapeutically important neurotransmitter-gated receptors whose ligand binding sites are formed by the convergence of six peptide loops (A-F).
Thompson, Andrew J., Thompson, A.J., M. Lochner, Lummis, S. C. R., Lummis, S.C.R., S. C. R. Lummis, Lochner, M., A. J. Thompson, Lochner, Martin, Thompson, Andrew James   +9 more
core   +2 more sources

Modelling and Experimental Verification of Step Response Overshoot Removal in Electrothermally-Actuated MEMS Mirrors

Micromachines, 2017
Micro-electro-mechanical system (MEMS) mirrors are widely used for optical modulation, attenuation, steering, switching and tracking. In most cases, MEMS mirrors are packaged in air, resulting in overshoot and ringing upon actuation.
Mengyuan Li, Qiao Chen, Yabing Liu, Yingtao Ding, Huikai Xie   +4 more
doaj   +1 more source

Leucine‐rich glioma inactivated 1 (LGI1) is a ganglioside‐binding protein

FEBS Letters, EarlyView.
Neuronal hyperexcitability associated with a decrease/absence of the extracellular protein LGI1 has been suggested to be primarily due to the downregulation of Kv1 channel expression. The molecular mechanisms underlying this decrease have not yet been elucidated.
Kévin Debreux, Christian Lévêque, Fodil Azzaz, Marion Sangiardi, Sarosh R Irani, Michael Seagar, Jacques Fantini, Oussama El Far   +7 more
wiley   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source