Results 21 to 30 of about 2,411,563 (322)

4‐nitrobenzoate inhibits 4‐hydroxybenzoate polyprenyltransferase in malaria parasites and enhances atovaquone efficacy

FEBS Letters, EarlyView.
Atovaquone is an antimalarial requiring potentiation for sufficient efficacy. We pursued strategies to enhance its activity, showing that 4‐nitrobenzoate inhibits 4‐hydroxybenzoate polyprenyltransferase, decreasing ubiquinone biosynthesis. Since atovaquone competes with ubiquinol in mitochondria, 4‐nitrobenzoate facilitates its action, potentiating ...
Ignasi Bofill Verdaguer, Matheus Felipe Santos, Maurício Mazzine Filho, Gabriela Oliveira Castro, Agustín Hernández, Manoel Aparecido Peres, Alejandro Miguel Katzin, Marcell Crispim   +7 more
wiley   +1 more source

Effect of Single-Point Incremental Forming Process Parameters on Roughness of the Outer Surface of Conical Drawpieces from CP Titanium Sheets

Advances in Mechanical and Materials Engineering
With the widespread use of numerically controlled machine tools, single-point incremental forming (SPIF) process has enjoyed growing interest in the industry.
Marcin Szpunar, Robert Ostrowski, Department of Manufacturing and Production Engineering, Faculty of Mechanical Engineering and Aeronautics, Rzeszów University of Technology, al. Powstancow Warszawy 8, 35-959 Rzeszow, Poland   +2 more
doaj   +1 more source

Risks related to the lack of lubrication on surface integrity in drilling

Heliyon, 2019
Drilling processes can significantly affect the surface integrity of metallic components. Thus, the control of the drilling process is of great interest for industry to ensure a satisfactory surface behavior.
Mathieu Girinon, Habib Karaouni, Ugo Masciantonio, Fabien Lefebvre, Erwan Jourden, Frédéric Valiorgue, Joël Rech, Eric Feulvarch   +7 more
doaj   +1 more source

Laser-Assisted Fabrication of NMR Resonators [PDF]

, 2004
A detection coil for use in nuclear resonance magnetic (NMR) spectroscopy and a method of manufacture thereof. At least two film layers of material are deposited on an outer surface of a cylindrical tube of dielectric material.
Allen, Susan D., Brey, William W.
core   +1 more source

Linked dimers of the AAA+ ATPase Msp1 reveal energetic demands and mechanistic plasticity for substrate extraction from lipid bilayers

FEBS Letters, EarlyView.
Cells must clear mislocalized or faulty proteins from membranes to survive. The AAA+ ATPase Msp1 performs this task, but dissecting how its six subunits work together is challenging. We engineered linked dimers with varied numbers of functional subunits to reveal how Msp1 subunits cooperate and use energy to extract proteins from the lipid bilayer ...
Deepika Gaur, Brian Acquaviva, Baylee A. Smith, Nathan Walker, Isabella Walter, Matthew L. Wohlever   +5 more
wiley   +1 more source

Laser processing of Ti6Al4V alloy: wetting state of surface and environmental dust effects

Heliyon, 2019
Laser processing of Ti6Al4V alloy surface, via repetitive pulses, is realized incorporating the nitrogen assisting gas. The texture characteristics of the surface and wetting state are analyzed.
B.S. Yilbas, H. Ali, A. Al-Sharafi, H. Al-Qahtani   +3 more
doaj   +1 more source

Mechanics of Hip Dysplasia Reduction in Infants Using the Pavlik Harness: A Physics Based Computational Model [PDF]

, 2013
Biomechanical factors influencing the reduction of dislocated hips with the Pavlik harness in patients of Developmental Dysplasia of the Hip (DDH) were studied using a three-dimensional computer model simulating hip reduction dynamics in (1) subluxated ...
Ardila, Orlando, Divo, Eduardo, Kassab, Alain, Moslehy, Faissal, Price, Charles, Rab, George   +5 more
core   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

DEVELOPING AUTHENTIC ASSESSMENT FOR MECHANICAL ENGINEERING SUBJECT OF VOCATIONAL SCHOOL STUDENTS (ESP) AT SMK N 2 OF BENGKULU

Journal of Applied Linguistics and Literature, 2018
This research was aimed to know the appropriate assessment, find out speaking’s authentic assessment material and find out the characteristics of authentic speaking assessment model for Mechanical Engineering of Vocational School.
Erlian Dwisnu, Syahriah Syahrial, I Wayan Dharmayana   +2 more
doaj   +5 more sources

Effect of nozzle geometry on critical-subcritical flow transitions

Heliyon, 2019
The geometry of converging-diverging nozzles affects the conditions at which critical-subcritical flow transition occurs. The objective of this work is to develop guidelines to identify the optimum nozzle geometry that maximizes critical pressure ratio ...
Jagmit Singh, Luis E. Zerpa, Benjamin Partington, Jose Gamboa   +3 more
doaj   +1 more source