Results 131 to 140 of about 3,007,216 (374)

Nonlinear forced vibration analysis of composite beam combined with DQFEM and IHB

AIP Advances, 2020
In this paper, a forced vibration model of composite beams under the action of periodic excitation force considering geometric nonlinearity is proposed. For the strain–displacement relationship, Timoshenko beam theory is used, and the element and system ...
Kwangchol Ri, Poknam Han, Inchol Kim, Wonchol Kim, Hyonbok Cha   +4 more
doaj   +1 more source

Computing Pathways to Systems Biology: Key Contributions of Computational Methods in Pathway Identification [PDF]

arXiv, 2013
Understanding large molecular networks consisting of entities such as genes, proteins or RNAs that interact in complex ways to drive the cellular machinery has been an active focus of systems biology. Computational approaches have played a key role in systems biology by complementing theoretical and experimental approaches.
arxiv  

A small PAM optimises target recognition in the CRISPR-Cas immune system [PDF]

arXiv, 2021
CRISPR-Cas is an adaptive immune mechanism that has been harnessed for a variety of genetic engineering applications: the Cas9 protein recognises a 2-5nt DNA motif, known as the PAM, and a programmable crRNA binds a target DNA sequence that is then cleaved.
arxiv  

Geographic proximity and firm-university innovation linkages: evidence from Great Britain [PDF]

, 2008
We investigate evidence for spatially mediated knowledge transfer from university research. We examine whether firms locate their R&D labs near universities, and whether those that do are more likely to co-operate with, or source knowledge from ...
Abramovsky, L., Simpson, H.
core  

Componential coding in the condition monitoring of electrical machines Part 2: application to a conventional machine and a novel machine [PDF]

, 2003
This paper (Part 2) presents the practical application of componential coding, the principles of which were described in the accompanying Part 1 paper.
A D Ball, B S Payne, C J S Webber, Chow M., Eisenmann R. C., Eren L., F Gu, Luo F., Lyon R. H., Payne B. S., Penman J., Starr A., Tavner P. J., Wowk V.   +13 more
core   +1 more source

Targeting the AKT/mTOR pathway attenuates the metastatic potential of colorectal carcinoma circulating tumor cells in a murine xenotransplantation model

Molecular Oncology, EarlyView.
Dual targeting of AKT and mTOR using MK2206 and RAD001 reduces tumor burden in an intracardiac colon cancer circulating tumor cell xenotransplantation model. Analysis of AKT isoform‐specific knockdowns in CTC‐MCC‐41 reveals differentially regulated proteins and phospho‐proteins by liquid chromatography coupled mass spectrometry. Circulating tumor cells
Daniel J. Smit, Thais Pereira‐Veiga, Helena Brauer, Michael Horn, Paula Nissen, Thomas Mair, Bente Siebels, Hannah Voß, Ruimeng Zhuang, Marie‐Therese Haider, Desiree Loreth, Margarita Iskhakova, Bele Lindemann, Julian Kött, Laure Cayrefourcq, Jasmin Wellbrock, Hartmut Schlüter, Klaus Pantel, Catherine Alix‐Panabières, Manfred Jücker   +19 more
wiley   +1 more source

Time, the final frontier

Molecular Oncology, EarlyView.
This article advocates integrating temporal dynamics into cancer research. Rather than relying on static snapshots, researchers should increasingly consider adopting dynamic methods—such as live imaging, temporal omics, and liquid biopsies—to track how tumors evolve over time.
Gautier Follain, Michal Dibus, Omkar Joshi, Guillaume Jacquemet   +3 more
wiley   +1 more source

Liquid–film triboelectric nanogenerator with the volume effect for low-frequency blue energy harvesting and shock detection

JPhys Energy
Blue energy is vital for sustainable development, providing a viable alternative to fossil fuels and contributing to climate change mitigation and environmental protection.
Weiyuan Wang, Hao Wang, Ping Wang, Qiuhong Li, Ruoxi Zhao, Yang Jin   +5 more
doaj   +1 more source

Optimal solution for the single-beam bridge crane girder using the Moth-Flame algorithm

Vojnotehnički Glasnik
Introduction/purpose: The paper analyses and optimizes the welded I-girder of the single-beam bridge crane with a U-profile as the top flange. This solution is to provide a lighter carrying structure, so the main goal is to minimize the weight of the ...
Goran V. Pavlović, Mile M. Savković, Nebojša B. Zdravković, Goran Đ. Marković, Predrag Z. Mladenović   +4 more
doaj   +1 more source

Ubiquitination of transcription factors in cancer: unveiling therapeutic potential

Molecular Oncology, EarlyView.
In cancer, dysregulated ubiquitination of transcription factors contributes to the uncontrolled growth and survival characteristics of tumors. Tumor suppressors are degraded by aberrant ubiquitination, or oncogenic transcription factors gain stability through ubiquitination, thereby promoting tumorigenesis.
Dongha Kim, Hye Jin Nam, Sung Hee Baek
wiley   +1 more source