Clinical Pharmacology &Therapeutics, EarlyView.Cofetuzumab pelidotin (Cofe‐P) is an anti‐protein tyrosine kinase 7 (PTK7) antibody‐drug conjugate (ADC) being investigated for the treatment of adults with PTK7‐expressing, recurrent non‐small cell lung cancer (NSCLC). The first‐in‐human (FIH) trial demonstrated tolerability of dosages ≤ 2.8 mg/kg once every 3 weeks (Q3W) and ≤ 3.2 mg/kg Q2W ...
Carla Biesdorf +8 more
wiley +1 more source
Embryonic development of the Mediterranean starfish Hacelia attenuata
Developmental Dynamics, EarlyView.Abstract Background Starfish play essential ecological roles as predators and ecosystem regulators; however, detailed developmental descriptions exist for only a handful of species, none of which are from the Mediterranean Sea. Results In this study, we provide the first full account of the development of the Mediterranean starfish Hacelia attenuata ...
Silvia Caballero‐Mancebo +3 more
wiley +1 more source
Variable pressure support ventilation vs. biphasic positive airway pressure/airway pressure release ventilation in experimental acute respiratory failure. [PDF]
BMC AnesthesiolBluth T +7 more
europepmc +1 more source
Developmental Dynamics, EarlyView.Development and differentiation of the atrial myocardium. Hemodynamic loading triggers shear stress response, which is essential for pectinate muscle formation; mechanical stretching is important for the expression of chamber myocardium markers and proper maturation of the atrial contractile and conductive properties.
C. Neradilova +7 more
wiley +1 more source
Clinical and nursing correlates of severity among chronically ill adults with aspiration pneumonia in Saudi Arabia: A retrospective cross-sectional study. [PDF]
Belitung Nurs JHassan EMG +10 more
europepmc +1 more source
Direct cortical stimulation–evoked symptoms in the human temporal pole: A systematic review
Epileptic Disorders, EarlyView.Abstract The temporal pole represents a key node within temporolimbic networks and may contribute to seizure generation in temporal lobe epilepsy. Direct cortical stimulation (DCS), performed during intracranial presurgical evaluation, is a valuable method for delineating the seizure onset zone by reproducing electro‐clinical features of a patient's ...
Yulia Novitskaya +1 more
wiley +1 more source
Esophageal Exclusion as a Damage-Control Strategy for Acute Esophageal Necrosis Secondary to Ruptured Stanford Type B Aortic Dissection: A Case Report. [PDF]
CureusRodriguez Rueda R, Koliakos N, Mboti F.
europepmc +1 more source
Artificial intelligence in preclinical epilepsy research: Current state, potential, and challenges
Epilepsia Open, EarlyView.Abstract Preclinical translational epilepsy research uses animal models to better understand the mechanisms underlying epilepsy and its comorbidities, as well as to analyze and develop potential treatments that may mitigate this neurological disorder and its associated conditions. Artificial intelligence (AI) has emerged as a transformative tool across
Jesús Servando Medel‐Matus +7 more
wiley +1 more source
Prevalence of Medical and Psychiatric Comorbidities in Paediatric ARFID: A Meta‐Analysis
European Eating Disorders Review, EarlyView.ABSTRACT Background Avoidant/Restrictive Food Intake Disorder (ARFID) is increasingly recognized as a complex paediatric feeding and eating disorder associated with significant medical and psychiatric burden. Methods This systematic review and meta‐analysis followed PRISMA guidelines and was prospectively registered in PROSPERO (CRD420251241490 ...
Nuria Blay Borch +8 more
wiley +1 more source
Non-invasive estimation of inspiratory muscle pressure and work of breathing by airway pressure extrapolation from the P0.1 maneuver during assisted ventilation. [PDF]
Sci RepBehmüller F +7 more
europepmc +1 more source