Results 121 to 130 of about 7,887 (176)

Shikonin Promotes Apoptosis in Multiple Myeloma Cells Through the PKM2‐AMPK‐PGC1α Metabolic Axis

Journal of Clinical Laboratory Analysis, EarlyView.
High PKM2 expression in MM is associated with a poor prognosis. Shikonin represents a promising PKM2‐targeted agent for MM therapy, offering a unique metabolic intervention strategy to improve drug resistance, bone disease, and the immune microenvironment. ABSTRACT Background Multiple myeloma (MM) is an incurable plasma malignancy.
Fengping Peng, Yu Gao, Ziqi Zhang, Ling Deng, Honglei Liu, Xiaowei Liang, Chunyan Liu, Rong Fu   +7 more
wiley   +1 more source

Characteristics of ascitic fluid and diagnosis of bacterial peritonitis in malignant ascites: An observational study

Journal of Hospital Medicine, EarlyView.
Abstract Background Bacterial peritonitis in patients with malignant ascites (BP‐MA) is an understudied, high‐mortality condition. While ascitic polymorphonuclear (PMN) cell count ≥ 250 cells/mm3 defines the diagnosis of spontaneous bacterial peritonitis (SBP) in patients with cirrhosis, an ascitic fluid parameter for the diagnosis of BP‐MA has not ...
Mark M. Kelly, Nicole Johnston, Joanne Kuznicki, Stacy A. Johnson, Hannah Imlay   +4 more
wiley   +1 more source

Periodontitis and breast cancer risk: A systematic review with meta‐epidemiological analysis

Journal of Periodontology, EarlyView.
Abstract Background The association between periodontitis and breast cancer (BC) risk has been reported, but with considerable variability in effect estimates across studies. This meta‐epidemiological study aimed to systematically evaluate how methodological characteristics of primary studies influence these reported effect estimates.
Rhayssa Kuhn Peitoxo, Catiusse Crestani Del Agnese, Mateus Cassol Comassetto, Leandro Machado Oliveira, Patricia Almeida Miguez, Raquel Pippi Antoniazzi   +5 more
wiley   +1 more source

Shaping the research agenda of pediatric gastroenterology, hepatology, and nutrition: The proposal from an Italian Society of Pediatric Gastroenterology, Hepatology and Nutrition (SIGENP) expert group

JPGN Reports, EarlyView.
Abstract The Italian Society of Pediatric Gastroenterology, Hepatology and Nutrition (SIGENP) recognized the need to define research priorities and identify knowledge gaps to guide future investigations in pediatric digestive health. Following international examples, SIGENP aimed to provide a structured framework that aligns scientific innovation with ...
Carlo Agostoni, Daniele Alberti, Renata Auricchio, Maria Elisabetta Baldassarre, Osvaldo Borrelli, Matteo Bramuzzo, Teresa Capriati, Carlo Catassi, Sabrina Cenni, Marco Crocco, Salvatore Cucchiara, Luigi Dall'Oglio, Paola De Angelis, Marco Deganello Saccomani, Fabiola Di Dato, Angelo Di Giorgio, Antonella Diamanti, Valeria Dipasquale, Enrico Felici, Ruggiero Francavilla, Valentina Giorgio, Luigi Greco, Raffaele lorio, Flavio Labriola, Paolo Lionetti, Elena Lionetti, Giuseppe Maggiore, Monica Malamisura, Claudia Mandato, Antonio Marseglia, Emanuele Nicastro, Lorenzo Norsa, Salvatore Oliva, Licia Pensabene, Elena Sofia Pieri, Paolo Quitadamo, Giusy Ranucci, Sara Renzo, Claudio Romano, Silvia Salvatore, Luca Scarallo, Maria Immacolata Spagnuolo, Annamaria Staiano, Caterina Strisciuglio, Renato Tambucci, Riccardo Troncone, Pietro Vajro   +46 more
wiley   +1 more source

Achieving clinical and histologic remission with tezepelumab in an adolescent with refractory eosinophilic gastrointestinal disease: A case report

JPGN Reports, EarlyView.
Abstract Tezepelumab is a human monoclonal antibody that binds to human thymic stromal lymphopoietin (TSLP), an epithelial cytokine that plays a role in Type 2 signaling. We describe a 17‐year‐old with a history of eosinophilic esophagitis (EoE) and eosinophilic gastroenteritis who demonstrated response to tezepelumab with both clinical and histologic ...
Destiny Newsome, Colby Sharlin, Cindy Salm Bauer, Shauna Schroeder   +3 more
wiley   +1 more source

Severe constipation‐associated postprandial abdominal pain in a pregnant native‐liver biliary atresia survivor after Kasai portoenterostomy: A case report

JPGN Reports, EarlyView.
ABSTRACT An 18‐year‐old woman with congenital biliary atresia status post Kasai portoenterostomy and magnetic resonance imaging‐reported chronic liver disease presented at 32 weeks’ gestation with 6 weeks of worsening postprandial epigastric/right upper quadrant pain, nausea, and poor oral intake.
Akram Alnounou, Ajay Katwala, Mohammad Alabbas, Bisher Sawaf, Arghyadeep Ganguly, EzzElDien A. Ibrahim, Fnu Vikash   +6 more
wiley   +1 more source

Anticancer potential of berberine: Molecular pathways and current clinical trial perspectives

JSFA reports, EarlyView.
Abstract Cancer is constantly rising mortality rates due to its late prognosis, poor management, and expensive treatment. Multi‐sectoral approaches for cancer management include hygienic practices, synthetic drug exploitation, radiation therapy, and diet modifications.
Muhammad Maaz, Muhammad Tauseef Sultan, Muhammad Israr, Waqas Ahmad Khan, Fahad Tanveer, Muzzamal Hussain, Muhammad Imran, Ahmed Mujtaba, Anjuman Gul Memon, Muhammad Atif, Entessar Al Jbawi   +10 more
wiley   +1 more source

Andrographolide Modulates Fibrogenic and Oxidative Stress Responses in Human Lung Fibroblasts

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Pulmonary fibrosis is a progressive lung disorder characterized by fibroblast activation and excessive extracellular matrix deposition. Andrographolide (ANDRO) has been reported to attenuate pulmonary fibrosis, but the underlying molecular mechanisms remain incompletely understood.
Yu‐Hsin Tseng, Yen‐Hsien Wu, Yi‐Ching Liu, I‐Chen Chen, Chung‐Yu Yeh, Shang‐En Huang, Ren‐Long Jan, Jwu‐Lai Yeh, Jong‐Hau Hsu   +8 more
wiley   +1 more source

WDR72 Drives Esophageal Squamous Cell Carcinoma Progression by Inhibiting Autophagy via the PI3K/Akt/mTOR Pathway

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Esophageal squamous cell carcinoma (ESCC) is an aggressive malignancy with a high rate of recurrence and metastasis, necessitating the identification of novel therapeutic targets. WD repeat‐containing protein 72 (WDR72) has been linked to various cancers, but its specific biological function and underlying mechanism in ESCC remain largely ...
Hao Wu, Zhong‐Xiang Jiang, Zheng Jiang
wiley   +1 more source

Relationship between gastric tube retention and swallowing dysfunction in comatose patients undergoing tracheotomy. [PDF]

Am J Transl Res
Yuan J, Shi R, Zhu Q, Zeng J.
europepmc   +1 more source