Results 101 to 110 of about 226,123 (296)
Molecular Oncology, EarlyView.Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz +15 more
wiley +1 more source
Experimental tests on a new harvesting system for Burley tobacco
Journal of Agricultural Engineering, 2013 The globalization of the tobacco production has led to a drop in competitiveness of the Italian tobacco on the world market. Burley is the main variety of tobacco cropped in Campania region of Southern Italy.
Salvatore Faugno +5 more
doaj +1 more source
Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway
Molecular Oncology, EarlyView.Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed +10 more
wiley +1 more source
Parylene-based electret power generators [PDF]
, 2008 n electret power generator is developed using a new electret made of a charged parylene HT® thin-film polymer. Here, parylene HT® is a room-temperature chemical-vapor-deposited thin-film polymer that is MEMS and CMOS compatible.
Lo, Hsi-wen, Tai, Yu-Chong
core +1 more source
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Visual analysis of fruit harvesting machine based on CiteSpace [PDF]
Guoshu xuebao[Objective] In the context of the acceleration of agricultural modernization, the development of fruit harvesting machinery is of great significance for improving the production efficiency of fruit industry and reducing labor costs.
YANG Daorina +5 more
doaj +1 more source
Effect of weed management strategies on the risk of enteric pathogen transfer into the food chain and lettuce quality [PDF]
, 2007 The hygienic quality of raw edible vegetables such as lettuce may be influenced by pathogen transfer from soil to plant, which might occur during weed control by hoeing or as splash-effects during rainfall.
Fischer-Arndt, M.T., Köpke, U.
core
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
Pelletization of invasive Reynoutria Japonica with spruce sawdust for energy recovery [PDF]
, 2018 The article focuses on processing of Reynoutria japonica an invasive alien species that is generally extirpated with major costs for its negative impact on biodiversity. It is the biodegradable waste that could be effectively used in energy industry.
Jezerská, Lucie +4 more
core
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source